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Publications

The Research Centre for Infectious Diseases has delivered major advances in our understanding of the host-pathogen interaction and the molecular mechanisms underlying diseases processes.

These landmark publications have been featured in high impact interdisciplinary journals.

Article level metrics, as recommended in the San Francisco Declaration on Research Assessment (DORA), for selected publications below are reported by Altmetric and the Faculty of 1000.

  • Landmark Publications
              1. Wielenga, M.C., Colak, S., Heijmans, J., van Lidth de Jeude, J.F., Rodermond, H.M., Paton, J.C., Paton, A.W., Vermeulen, L., Medema, J.P., van den Brink, G.R. (2015) ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy. Cell Reports doi:10.1016/j.celrep.2015.09.016
              2. Begg, S.L., Eijkelkamp, B.A., Luo, Z., Couñago, R.M., Morey, J.R., Maher, M.J., Ong C.Y., McEwan, A.G., Kobe, B., O'Mara M.L., Paton, J.C., and McDevitt, C.A. (2015) Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae. Nature Communications 6:6418 [pdf]
              3. Ng P.S.K., Böhm R., Hartley-Tassell L.E., Steen J.A., Wang H., Lukowski S.W., Hawthorne P.L., Trezise A.E.O., Coloe P.J., Grimmond S.M., Haselhorst T., von Itzstein M., Paton A.W., Paton J.C. and Jennings M.P. (2014). Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors. Nature Communications 5:5750
              4. Mina, M.M., Luciani, F., Cameron, B., Bull, R.A., Beard, M.R., Booth, D., Lloyd, A.R. (2015) Resistance to hepatitis C virus: potential genetic and immunological determinants. Lancet Infectious Diseases 15:451-60.
              5. Shewell, L.K., Harvey, R.M., Higgins, M.A., Day, C.J., Hartley-Tassell, L.E., Chen, A.Y., Gillen, C.M., James, D.B.A., Alonzo III, F., Torres, V.J., Walker, M.J., Paton, A.W., Paton J.C. and Jennings, M.P. (2015) The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity. Proceedings of the National Academy of Sciences of the United States of America 111:E5312-20
              6. Knippenberg, S., Ueberberg, B., Maus, R., Bohling, J., Ding, N., Tort Tarres, M., Hoymann, H.G., Jonigk, D., Izykowski, N., Paton, J.C., Ogunniyi, A.D., Lindig, S., Bauer, M., Welte, T., Seeger, W., Guenther, A., Sisson, T.H., Gauldie, J., Kolb, M., Maus, U.A. Streptococcus pneumoniae triggers progression of pulmonary fibrosis through pneumolysin. (2015) Thorax. 70:636-46.
              7. Josling, G.A., Petter, M., Oehring, S.C., Gupta, A.P., Dietz, O., Wilson, D.W., Schubert, T., Längst G., Gilson, P.R., Crabb, B.S., Moes, S., Jenoe, P., Lim, S.W., Brown, G.V., Bozdech, Z., Voss, T.S., Duffy, M.F. A Plasmodium falciparum bromodomain protein regulates invasion gene expression. (2015) Cell & Host Microbe. 17:741-51.
              8. Manso, A.S., Chai, M.H., Atack, J.M., Furi, L., Croix, M.D.S., Haigh, R., Trappetti, C., Ogunniyi, A.D., Shewell, L.K., Boitano, M., Clark, T.A., Korlach, J., Blades, M., Mirkes, E., Gorban, A., Paton, J.C., Jennings, M.P., and Oggioni, M.R. (2014). A random six-phase switch regulates pneumococcal virulence via global epigenetic changes. Nature Communications. 5:5055
              9. Lu, M., Lawrence, D.A., Marsters, S., Acosta-Alvear, D., Kimmig, P., Mendez, A., Paton, A.W., Paton, J.C., Walter, P., and Ashkenazi, A. (2014). Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis. Science. 342:98-101.
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              10. Couñago, R.M.*, Ween, M.P.*, Begg S.L., Bajaj, M., Zuegg, J., O'Mara, M.L., Cooper, M.A., McEwan, A.G., Paton, J.C., Kobe, B., and McDevitt, C.A. (2014) Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chemical Biology. 10:35-41. [pdf] [*equal first author]
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              11. Brotcke Zumsteg A., Goosmann C., Brinkmann V., Morona R., Zychlinsky A. (2014). IcsA is a Shigella flexneri adhesin regulated by the type III secretion system and required for pathogenesis. Cell Host & Microbe. 15:435-45.
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              12. Eyre, N.S., and Beard, M.R.HCV NS5A Inhibitors disrupt replication factory formation: A novel mechanism of antiviral action. (2014) Gastroenterology. 147:959-62.
              13. Shak, J.R., Ludewick, H.P., Sakai, F., Harvey, R.M., Paton, J.C., Klugman, K.P., and Vidal, J.E. (2013). A novel role for the Streptococcus pneumoniae toxin pneumolysin in the assembly of biofilms. mBio. 4:e00655-13.
              14. Helbig, K.J., Carr, J.M., Calvert, J.K., Wati, S., Clarke, J.N., Eyre N.S., Narayana, S.K., Fiches G.N., McCartney, E.M., Beard, M.R. Viperin is induced following dengue virus type-2 (DENV-2) infection and has anti-viral actions requiring the C-terminal end of viperin. (2013) PLoS Neglected Tropical Diseases 7:e2178.
              15. Heijmans, J., van Lidth de Jeude, J.F., Koo, B.K., Rosekrans, S.L., Wielenga, M.C.B., van de Wetering, M., Ferrante, M., Lee, A.S., Onderwater, J.J.M., Paton, J.C., Paton, A.W., Mommaas, A.M., Kodach, L.L., Hardwick, J.C., Hommes, D.W., Clevers, H., Muncan, V., and van den Brink, G.R. (2013). ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. Cell Reports 3:1-12.
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              16. Mahdi, L.K., Wang, H., Van der Hoek, M.B., Paton, J.C., and Ogunniyi, A.D. (2012). Identification of a novel pneumococcal vaccine antigen preferentially expressed during meningitis in mice. Journal of Clinical Investigation. 122:2208-2220. 
              17. Nasr, N., Maddocks, S., Turville, S.G., Harman, A.N., Woolger N, Helbig, K.J., Wilkinson, J., Bye, C.R., Wright, T.K., Rambukwelle D, Donaghy, H., Beard, M.R., Cunningham, A.L. (2012) HIV-1 infection of human macrophages directly induces viperin which inhibits viral production. Blood. 120:778-88
              18. McDevitt, C.A., Ogunniyi, A.D., Valkov, E., Lawrence, M.C., Kobe, B., McEwan, A.G., and Paton, J.C. (2011) A molecular mechanism for bacterial susceptibility to zinc. PLoS Pathogens 7:e1002357 [pdf]
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              19. Schäuble, N., Lang, S., Jung, M., Cappel, S., Schorr, S., Ulukan, O., Linxweiler, J., Dudek, J., Blum, R., Helms, V., Paton, A.W., Paton, J.C., Cavalié, A., and Zimmermann, R. (2012) BiP-mediated closing of the Sec61 channel via loop 7 interaction limits Ca2+ leakage from the ER. EMBO Journal. 31:3282-3296.
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              20. Goodwin, E.C., Lipovsky, A., Inoue, T., Magaldi, T.G., Edwards, A.P.B., Van Goor, K.E.Y., Paton, A.W., Paton, J.C., Atwood, W.J., Tsai, B., and DiMaio, D. (2011). BiP and multiple DNAJ molecular chaperones in the endoplasmic reticulum are required for efficient SV40 infection. mBio. 2: e00101-11.
              21. Paton, J.C., and Ogunniyi, A.D. (2011). Evicting the pneumococcus from its nasopharyngeal lodgings. Cell Host & Microbe. 9:89-91
              22. Helbig, K.J., Eyre, N.S., Yip, E., Narayana S, Li K, Fiches G, McCartney, E.M., Jangra, R.K., Lemon, S.M., Beard, M.R. (2011) The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A. Hepatology 54:1506-17
              23. Eyre, N. and Beard, M.R. (2010) The SR-BI partner PDZK1 facilitates hepatitis C virus entry. PLoS Pathogens 6:e1001130
              24. Eyre, N. and Beard, M.R. (2010) Hepatitis C virus infection in living colour. Hepatology. 51:1852-5
              25. Hu, C.A., Dougan, S.K., Winter, S.V., Paton, A.W., Paton, J.C., and Ploegh, H.L. (2009). Subtilase cytotoxin cleaves newly synthesised BiP and blocks antibody secretion in B lymphocytes. Journal of Experimental Medicine. 206:2429-2440.
              26. Kadioglu A., Weiser J.N., Paton J.C., and Andrew P.W. (2008). The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease. Nature Reviews Microbiology 6:288-301.
              27. Byres, E., Paton, A.W., Paton, J.C., Löfling, J.C., Smith, D.F., Wilce, M.C.J., Talbot, U.M., Chong, D.C., Yu, H., Huang, S., Chen, X., Varki, N.M., Varki, A., Rossjohn, J., and Beddoe, T. (2008). Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin. Nature. 456: 648-652.
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Peer-Reviewed Publications

The research intensive focus of the RCID has delivered more than 230 articles in peer-reviewed journals across numerous disciplines since it was established in 2008. This places the RCID as one of the most collaborative and prolific centres within the University of Adelaide.

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  • 2015
    • Wielenga, M.C., Colak, S., Heijmans, J., van Lidth de Jeude, J.F., Rodermond, H.M., Paton, J.C., Paton, A.W., Vermeulen, L., Medema, J.P., van den Brink, G.R. (2015) ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy. Cell Reports doi:10.1016/j.celrep.2015.09.016
    • Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, Ma H, Inoue T, Gao B, Kim H, Bu P, Guber RD, Shen X, Lee AH, Iwawaki T, Paton AW, Paton JC, Fang D, Tsai B, Yates Iii JR, Wu H, Kersten S, Long Q, Duhamel GE, Simpson KW, Qi L. IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. (2015) Nat Cell Biol. 17:1546-55. doi: 10.1038/ncb3266
    • Kara EE, McKenzie DR, Bastow CR, Gregor CE, Fenix KA, Ogunniyi AD, Paton JC, Mack M, Pombal DR, Seillet C, Dubois B, Liston A, MacDonald KP, Belz GT, Smyth MJ, Hill GR, Comerford I, McColl SR.CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells. (2015) Nat Commun. 6:8644.
    • Luo Z, Morey JR, McDevitt CA, Kobe B. Heterogeneous nucleation is required for crystallization of the ZnuA domain of pneumococcal AdcA. (2015) Acta Crystallogr F Struct Biol Commun. 71:1459-1464
    • Eijkelkamp BA, Pederick VG, Plumptre CD, Harvey RM, Hughes CE, Paton JC, McDevitt CA. The first histidine triad motif of PhtD is critical for zinc homeostasis in Streptococcus pneumoniae. (2015) Infection and Immunity. doi: 10.1128/IAI.01082-15 
    • Amin Z, Harvey RM, Wang H, Hughes CE, Paton AW, Paton JC, Trappetti C. Isolation Site Influences Virulence Phenotype of Serotype 14 Streptococcus pneumoniae Strains Belonging to Multilocus Sequence Type 15. (2015)  Infect Immun. 83:4781-90. doi: 10.1128/IAI.01081-15
    • Robb M, Robb CS, Higgins MA, Hobbs JK, Paton JC, Boraston AB. A second β-hexosaminidase encoded in the Streptococcus pneumoniae genome provides an expanded biochemical ability to degrade host glycans. (2015) J Biol Chem. 
    • Chen A, Mann B, Gao G, Heath R, King J, Maissoneuve J, Alderson M, Tate A, Hollingshead SK, Tweten RK, Briles DE, Tuomanen EI, Paton JC. Multivalent Pneumococcal Protein Vaccines Comprising Pneumolysoid with Epitopes/Fragments of CbpA and/or PspA Elicit Strong and Broad Protection. (2015) Clin Vaccine Immunol. 22:1079-89.
    • Deplazes, E.*, Begg, S.L.*, van Wonderen, J.H., Cambpell, R., Kobe, B. Paton, J.C., MacMillan F., McDevitt, C.A.# and O'Mara M.L.# (2015) Characterising the conformational dynamics of metal-free PsaA using molecular dynamics simulations and electron paramagnetic resonance spectroscopy. Biophysical Chemistry. Accepted. doi: 10.1016/j.bpc.2015.08.004 [*equal first author; #co-corresponding authors]
    • Pederick, V.G., Eijkelkamp, B.A., Begg, S.L., Ween, M.P., McAllister, L.J., Paton, J.C., and McDevitt, C.A. (2015) ZnuA and zinc homeostasis in Pseudomonas aeruginosa. Scientific Reports. 5:13139
    • Begg, S.L., Eijkelkamp, B.A., Luo, Z., Couñago, R.M., Morey, J.R., Maher, M.J., Ong C.Y., McEwan, A.G., Kobe, B., O'Mara M.L., Paton, J.C., and McDevitt, C.A. (2015) Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae. Nature Communications 6:6418
    • Eijkelkamp, B.A., McDevitt, C.A., and Kitten, T. (2015) Manganese uptake and streptococcal virulence. Biometals. DOI: 10.1007/s10534-015-9826-z
    • Bajaj M., Mamidyala, S.K., Zuegg, J., Begg, S.L., Ween, M.P., Luo, Z., Huang, J.X., McEwan, A.G., Kobe, B., Paton, J.C., McDevitt, C.A., and Cooper M.A. (2015) Discovery of novel Pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach. ACS Chemical Biology 10:1511-20
    • McDevitt, C.A., Begg, S.L., and Paton, J.C. (2015) Metal ion toxicity and oxidative stress in Streptococcus pneumoniae. In: Stress and Environmental Control of Gene Expression in Bacteria. F.J. de Bruijn (Editor). In press.
    • Morey J.R., McDevitt C.A.#, and Kehl-Fie T.E.# (2015) Host-imposed manganese starvation of invading pathogens: two routes to the same destination. Biometals. 28:509-519
    • Narayana S.K., Helbig K.J., McCartney E.M., Eyre N.S., Bull R.A., Eltahla A., Lloyd A.R., Beard M.R. (2015) The interferon-induced transmembrane proteins - IFITM1, IFITM2 and IFITM3 inhibit hepatitis C virus entry. The Journal of Biological Chemistry. doi: 10.1074/jbc.M115.657346
    • Calvert J.K., Helbig K.J., Dimasi D., Cockshell, M., Beard M.R., Pitson S.M., Bonder C. and Carr, J.M. (2015) Dengue virus infection of primary endothelial cells (EC) induces innate immune responses, changes in EC function and is restricted by interferon stimulated responses. Journal of Interferon and Cytokine Research 35:654-65. doi: 10.1089/jir.2014.0195.
    • Milic, N.L., Davis S., Carr J.M., Isberg S., Beard M.R. and Helbig K.J. (2015) Sequence analysis and characterization of virally induced viperin in the saltwater crocodile (Crocodylus porosus). Developmental and Comparative Immunology 51:108-15. doi: 10.1016/j.dci.2015.03.001. 
    • Mina, M.M., Luciani, F., Cameron, B., Bull, R.A., Beard, M.R., Booth, D., Lloyd, A.R. (2015) Resistance to hepatitis C virus: potential genetic and immunological determinants. Lancet Infectious Diseases 15:451-60. doi: 10.1016/S1473-3099(14)70965-X.
    • Nath P., Morona R. Detection of Wzy/Wzz interaction in Shigella flexneri. (2015) Microbiology. doi: 10.1099/mic.0.000132
    • Paton A.W., Chen A.Y., Wang H., McAllister L.J., Höggerl F., Mayr U.B., Shewell L.K., Jennings M.P., Morona R., Lubitz W., Paton J.C. Protection against shiga-toxigenic Escherichia coli by non-genetically modified organism receptor mimic bacterial ghosts. (2015) Infect Immun. 83:3526-33. doi: 10.1128/IAI.00669-15
    • Tran E.N., Attridge S.R., Teh M.Y., Morona R. Shigella flexneri cell-to-cell spread, and growth and inflammation in mice, is limited by the outer membrane protease IcsP. (2015) FEMS Microbiol Lett. 362:fnv088. doi: 10.1093/femsle/fnv088.
    • Doyle M.T., Tran E.N., Morona R. The passenger-associated transport repeat promotes virulence factor secretion efficiency and delineates a distinct autotransporter subtype. (2015) Mol Microbiol. 97:315-29. doi: 10.1111/mmi.13027.
    • Doyle M.T., Grabowicz M., May K.L., Morona R. Lipopolysaccharide surface structure does not influence IcsA polarity. (2015) FEMS Microbiol Lett. 362:fnv042. doi: 10.1093/femsle/fnv042.
    • Nath P., Morona R. Mutational analysis of the major periplasmic loops of Shigella flexneri Wzy: identification of the residues affecting O antigen modal chain length control, and Wzz-dependent polymerization activity. (2015) Microbiology. 161:774-85. doi: 10.1099/mic.0.000042.
    • Doyle MT, Grabowicz M, Morona R. (2015) A small conserved motif supports polarity augmentation of Shigella flexneri IcsA. Microbiology. doi: 10.1099/mic.0.000165.
    • Whittall J.J., Morona R., Standish A.J. Topology of Streptococcus pneumoniae CpsC, a polysaccharide copolymerase and bacterial protein tyrosine kinase adaptor protein. (2015) J Bacteriol. 197(1):120-7. doi: 10.1128/JB.02106-14.
    • Nath P., Tran E.N., Morona R. Mutational analysis of the Shigella flexneri O-antigen polymerase Wzy: identification of Wzz-dependent Wzy mutants. (2015) J Bacteriol. 197(1):108-19. doi: 10.1128/JB.01885-14.
    • Tse E., Helbig K.J., Van der Hoek K., McCartney E.M., Van der Hoek M., George J., Beard M.R. Fatty acids induce a pro-inflammatory gene expression profile in Huh-7 cells that attenuates the anti-HCV action of interferon. (2015) J Interferon Cytokine Res. 35:392-400. doi: 10.1089/jir.2014.0165.
    • Aloia A.L., Eyre N.S., Black S., Bent S.J., Gaeguta A., Guo Z., Narayana S.K., Chase R., Locarnini S., Carr J.M., Howe J.A., Beard M.R. Generation of a chimeric hepatitis C replicon encoding a genotype-6a NS3 protease and assessment of boceprevir (SCH503034) sensitivity and drug-associated mutations. (2015) Antivir Ther. 20:271-80. doi: 10.3851/IMP2850.
    • Chen A, Mann B, Gao G, Heath R, King J, Maissoneuve J, Alderson M, Tate A, Hollingshead SK, Tweten RK, Briles DE, Tuomanen EI, Paton JC. Multivalent pneumococcal protein vaccines comprising pneumolysoid with epitopes/fragments of CbpA and/or PspA elicit strong and broad protection. (2015) Clin Vaccine Immunol. pii: CVI.00293-15.
    • Adomako A, Calvo V, Biran N, Osman K, Chari A, Paton JC, Paton AW, Moore K, Schewe DM, Aguirre-Ghiso JA. Identification of markers that functionally define a quiescent multiple myeloma cell sub-population surviving bortezomib treatment. (2015) BMC Cancer. 15:444. doi: 10.1186/s12885-015-1460-1
    • Knippenberg, S., Ueberberg, B., Maus, R., Bohling, J., Ding, N., Tort Tarres, M., Hoymann, H.G., Jonigk, D., Izykowski, N., Paton, J.C., Ogunniyi, A.D., Lindig, S., Bauer, M., Welte, T., Seeger, W., Guenther, A., Sisson, T.H., Gauldie, J., Kolb, M., Maus, U.A. Streptococcus pneumoniae triggers progression of pulmonary fibrosis through pneumolysin. (2015) Thorax. 70:636-46. doi: 10.1136/thoraxjnl-2014-206420.
    • Wilson DW, Goodman CD, Sleebs BE, Weiss GE, de Jong NW, Angrisano F, Langer C, Baum J, Crabb BS, Gilson PR, McFadden GI, Beeson JG. Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum. (2015) BMC Biol. 13:52. doi: 10.1186/s12915-015-0162-0.
    • Josling, G.A., Petter, M., Oehring, S.C., Gupta, A.P., Dietz, O., Wilson, D.W., Schubert, T., Längst G., Gilson, P.R., Crabb, B.S., Moes, S., Jenoe, P., Lim, S.W., Brown, G.V., Bozdech, Z., Voss, T.S., Duffy, M.F. A Plasmodium falciparum bromodomain protein regulates invasion gene expression. (2015) Cell Host Microbe. 17:741-51. doi: 10.1016/j.chom.2015.05.009.
    • Bui LM, Hoffmann P, Turnidge JD, Zilm PS, Kidd SP. Prolonged growth of a clinical Staphylococcus aureus strain selects for a stable small-colony-variant cell type. (2015) Infect Immun. 83(2):470-81. doi: 10.1128/IAI.02702-14.
    • Jiang D, Tikhomirova A, Bent SJ, Kidd SP. A discrete role for FNR in the transcriptional response to moderate changes in oxygen by Haemophilus influenzae Rd KW20. (2015) Res Microbiol. doi: 10.1016/j.resmic.2015.09.00
    • Tikhomirova A, Trappetti C, Paton JC, Kidd SP. The outcome of H. influenzae and S. pneumoniae inter-species interactions depends on pH, nutrient availability and growth phase. (2015) Int J Med Microbiol. doi: 10.1016/j.ijmm.2015.09.003
    • Jiang D, Tikhomirova A, Kidd SP. Haemophilus influenzae strains possess variations in the global transcriptional profile in response to oxygen levels and this influences sensitivity to environmental stresses. (2015) Res Microbiol.  doi: 10.1016/j.resmic.2015.08.004.
    • Tikhomirova A, Jiang D, Kidd SP. A new insight into the role of intracellular nickel levels for the stress response, surface properties and twitching motility by Haemophilus influenzae. (2015) Metallomics. 7:650-61. doi: 10.1039/c4mt00245h.
    • Bui LM, Turnidge JD, Kidd SP. The induction of Staphylococcus aureus biofilm formation or Small Colony Variants is a strain-specific response to host-generated chemical stresses. (2015) Microbes Infect. 17:77-82. doi: 10.1016/j.micinf.2014.09.009.
    • Bui LM, Kidd SP. (2015) A full genomic characterization of the development of a stable Small Colony Variant cell-type by a clinical Staphylococcus aureus strain. Infect Genet Evol. doi: 10.1016/j.meegid.2015.10.011.
  • 2014
    • Shewell, L.K., Harvey, R.M., Higgins, M.A., Day, C.J., Hartley-Tassell, L.E., Chen, A.Y., Gillen, C.M., James, D.B.A., Alonzo III, F., Torres, V.J., Walker, M.J., Paton, A.W., Paton J.C. and Jennings, M.P. (2015) The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity. Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.1412703111
    • Ng P.S.K., Böhm R., Hartley-Tassell L.E., Steen J.A., Wang H., Lukowski S.W., Hawthorne P.L., Trezise A.E.O., Coloe P.J., Grimmond S.M., Haselhorst T., von Itzstein M., Paton A.W., Paton J.C. and Jennings M.P. (2014). Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors. Nature Communications doi: 10.1038/ncomms6750
    • Leonard, A., Paton, A.W., Paton, J.C., and Fazal, F. (2014). Preconditioning with endoplasmic reticulum stress ameliorates endothelial cell inflammation. PLoS One. 9: e110949.
    • Feng, P.C., Delannoy, S., Lacher, D.W., Dos Santos, L.F., Beutin, L., Fach, P., Rivas, M., Hartland, E.L., Paton, A.W., and Guth, B.E. (2014). Genetic diversity and virulence potential of Shiga toxin-producing Escherichia coli O113:H21 strains isolated from clinical, environmental, and food sources. Appl. Environ. Microbiol. 80:4757-4763.
    • Mahdi L.K., Deihimi, T., Zamansani, F., Fruzangohar, M., Adelson, D.L., Paton, J.C., Ogunniyi, A.D., and Ebrahimie, E. (2014). A functional genomics catalogue of activated transcription factors during pathogenesis of pneumococcal disease. BMC Genomics. 15:769.
    • Manso, A.S., Chai, M.H., Atack, J.M., Furi, L., Croix, M.D.S., Haigh, R., Trappetti, C., Ogunniyi, A.D., Shewell, L.K., Boitano, M., Clark, T.A., Korlach, J., Blades, M., Mirkes, E., Gorban, A., Paton, J.C., Jennings, M.P., and Oggioni, M.R. (2014). A random six-phase switch regulates pneumococcal virulence via global epigenetic changes. Nature Commun. 5:5055.
    • Pederick, V.G., Eijkelkamp, B.A., Ween, M.P., Begg, S.L., Paton, J.C., and McDevitt, C.A. (2014). The acquisition and role of molybdate in Pseudomonas aeruginosa. Appl. Environ. Microbiol. 80:6843-6852.
    • Plumptre, C.D., Hughes, C.E., Harvey, R.M., Eijkelkamp, B.A., McDevitt, C.A., and Paton, J.C. (2014). Overlapping functionality of the Pht proteins in zinc homeostasis of Streptococcus pneumoniae. Infect. Immun. 82:4315-4324.
    • van Wonderen J.H., McMahon R.M., O'Mara M.L., McDevitt C.A., Thomson A.J., Kerr I.D., MacMillan F., and Callaghan R. (2014) The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis. FEBS Journal. 281:2190-201 [pdf]
    • Pollock, N.L., McDevitt, C.A., Collins, R.F., Niesten, P.H.M., Prince, S., Kerr, I.D., Ford, R.C., and Callaghan, R. (2014) Improving the stability and function of purified ABCB1 and ABCA4: The influence of membrane lipids. Biochim Biophys Acta. 1838:134-47. [pdf]
    • Potter, A.J., and Paton, J.C. (2014). Spermidine biosynthesis and transport modulates pneumococcal autolysis. J. Bacteriol. 196:3556-3561.
    • Ogunniyi, A.D., and Paton, J.C. (2014). Vaccine potential of pneumococcal proteins. In press. In: Brown, J., Hammerschmidt, S., and Orihuela, C. (eds). Streptococcus pneumoniae: Molecular mechanisms of host-pathogen interactions. Elsevier.
    • Hughes, C.E., Harvey, R.M., Plumptre, C.D., and Paton, J.C. (2014). Development of primary invasive pneumococcal disease by serotype 1 pneumococci is driven by early increased type I interferon response in the lung. Infect. Immun. 82:3919-3926.
    • Harvey, R.M., Hughes, C.E., Paton, A.W., Trappetti, C., Tweten, R.K., and Paton, J.C. (2014). The impact of pneumolysin on the macrophage response to Streptococcus pneumoniae is strain-dependent. PLoS One. 9:e103625. 
    • Fucho1, R., Martínez, L., Baulies, A., Tarrats, N., Fernandez, A., Ribas, V., Astudillo, A.M., Balsinde, J., Garcia-Rovés, P., Elena, M., Bergheim, I., Lotersztajn, S., Trautwein, C., Appelqvist, H., Paton, A.W., Paton, J.C., Kaplowitz, N., Fernandez-Checa, J.C., and García-Ruiz, C. (2014). ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis. J. Hepatol. In press (accepted 10/6/14).
    • Hostetter, S.J., Helgerson, A.F., Paton, J.C., Paton, A.W., and Cornick, N.A. (2014). Therapeutic use of a receptor mimic probiotic reduces intestinal Shiga toxin levels in a piglet model of hemolytic uremic syndrome. BMC Res Notes. 7:331. 
    • Lu, M., Lawrence, D.A., Marsters, S., Acosta-Alvear, D., Kimmig, P., Mendez, A., Paton, A.W., Paton, J.C., Walter, P., and Ashkenazi, A. (2014). Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis. Science 342:98-101.
    • Wang, H., Rogers, T.J., Paton, J.C., and Paton, A.W. (2014). Differential effects of Escherichia coli subtilase cytotoxin and Shiga toxin 2 on chemokine and pro-inflammatory cytokine expression in human macrophage, colonic epithelial and brain microvascular endothelial cell lines. Infect. Immun. 82:3567-3579.
    • Zacchi, L.F., Wu, H.-C., Bell, S.L., Millen, L., Paton, A.W., Paton, J.C., Thomas, P.J., Zolkiewski, M., and Brodsky, J.L. (2014). The BiP molecular chaperone plays multiple roles during the biogenesis of TorsinA, a AAA+ ATPase associated with the neurological disease Primary Torsion Dystonia. J. Biol. Chem. 289:12727-12747.
    • Eijkelkamp, B.A., Morey, J.R., Ween, M.P., Ong, C.Y., McEwan, A.G., Paton, J.C., and McDevitt, C.A. (2014). Extracellular zinc competitively inhibits manganese uptake and compromises oxidative stress management in Streptococcus pneumoniae. PLoS One. 9:e89427.
    • Márquez, L.B., Velázquez, N., Repetto, H.A., Paton, A.W., Paton, J.C., Ibarra, C., and Silberstein, C. (2014). Effects of Escherichia coli subtilase cytotoxin and Shiga toxin 2 on primary cultures of human renal tubular epithelial cells. PLoS One. 9: e87022.
    • Plumptre, C.D., Eijkelkamp, B.A., Morey, J.R., Behr, F., Couñago, R.M., Ogunniyi, A.D., Kobe, B., O'Mara, M.L., Paton, J.C., and McDevitt, C.A. (2014). AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in Streptococcus pneumoniae. Mol. Microbiol. 91:834-851.
    • Couñago, R.M., Ween, M.P., Begg, S.L., Bajaj, M., Zuegg, J., O'Mara, M.L., Cooper, M.A., McEwan, A.G., Paton, J.C., Kobe, B., and McDevitt, C.A. (2014). Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chem. Biol. 10:35-41.
    • Long Bui M.G., Turnidge J.D., Kidd S.P. (2014). The induction of Staphylococcus aureus biofilm formation or Small Colony Variants is a strain-specific response to host-generated chemical stresses. Microbes Infect. 
    • Ishak N., Tikhomirova A., Bent S.J., Ehrlich G.D., Hu F.Z., Kidd S.P. (2014) There is a specific response to pH by isolates of Haemophilus influenzae and this has a direct influence on biofilm formation. BMC Microbiol. doi: 10.1186/1471-2180-14-47
    • Standish A.J., Whittall J.J., Morona R. (2014). Tyrosine phosphorylation enhances activity of pneumococcal autolysin LytA. Microbiology. doi: 10.1099/mic.0.080747-0.
    • Lum M., Morona R. (2014). Myosin IIA is essential for Shigella flexneri cell-to-cell spread. Pathog Dis. doi: 10.1111/2049-632X.12202.
    • Lum M., Morona R. (2014) Dynamin-related protein Drp1 and mitochondria are important for Shigella flexneri infection. Int J Med Microbiol. 304:530-41.
    • Brotcke Zumsteg A., Goosmann C., Brinkmann V., Morona R., Zychlinsky A. (2014). IcsA is a Shigella flexneri adhesin regulated by the type III secretion system and required for pathogenesis. Cell Host Microbe. 15:435-45.
    • Kalynych S., Morona R., Cygler M. (2014). Progress in understanding the assembly process of bacterial O-antigen. FEMS Microbiol Rev. 38:1048-65.
    • Tran E.N., Papadopoulos M., Morona R. (2014). Relationship between O-antigen chain length and resistance to colicin E2 in Shigella flexneri. Microbiology. 160:589-601
    • Standish A.J., Morona R. (2014). The role of bacterial protein tyrosine phosphatases in the regulation of the biosynthesis of secreted polysaccharides. Antioxid Redox Signal. 20:2274-89.
    • Aloia, A.L., Eyre, N.S., Black, S., Bent, S.J., Gaeguta, A., Guo, Z., Narayana, S.K., Chase, R., Locarnini, S., Carr, J.M., Howe, J.A., Beard, M.R. (2014) Generation of a chimeric hepatitis C replicon encoding a genotype-6a NS3 protease and assessment of boceprevir (SCH503034) sensitivity and drug-associated mutations. Antivir Ther. doi: 10.3851/IMP2850.
    • Beard, M.R., Ffrench, R., Gowans, E.J., Helbig, K.J., Eyre, N.M., Douglas, M.M., Grebely, J., Ahlenstiel, G., Locarnini, S., George, J., Shackel, N.A., White, P.A., Thompson, A.J., Drummer, H.E. (2014) A summary of the 20th International Symposium on Hepatitis C Virus and Related Viruses. Gastroenterology. 147:e1-4.
    • Eyre, N.S., Fiches, G.N., Aloia, A.L., Helbig, K.J., McCartney EM, McErlean, C.S., Li, K., Aggarwal, A., Turville, S.G., Beard, M.R. (2014) Dynamic imaging of the hepatitis C virus NS5A protein during a productive infection. J. Virol. 88:3636-52
    • Helbig, K.J., Beard, M.R. (2014) The role of viperin in the innate antiviral response. J Mol Biol. 426:1210-9.
    • Eyre, N.S., and Beard, M.R. (2014) HCV NS5A Inhibitors disrupt replication factory formation: A novel mechanism of antiviral action. Gastroenterology. 147:959-62.
  • 2013

    • Heng S., McDevitt C.A., Stubing D.B., Whittall J.J., Thompson J.G., Engler T.K., Abell A.D. and Monro T.M. (2013) Microstructured optical fibers and live cells: a water-soluble, photochromic zinc sensor. Biomacromolecules. 14:3376-9. [pdf]
    • Basavanna, S., Chimalapati, S., Maqbool, A., Rubbo, B., Yuste, Y., Wilson, R.J., Hosie, A., Ogunniyi, A.D., Paton, J.C., Thomas, G., and Brown, J.S. (2013). The effects of methionine acquisition and synthesis on Spreptococcus pneumoniae growth and virulence. PLoS One. 8:e49638.
    • Ong, C.Y., Potter, A.J., Trappetti, C., Walker, M.J., Jennings, M.P., Paton, J.C., and McEwan, A.G. (2013) Interplay between manganese and iron in pneumococcal pathogenesis: role of the orphan response regulator RitR. Infect Immun. 81:421-429.
    • Trappetti, C., van der Maten, E., Amin, Z., Potter, A.J., Chen, A.Y., van Mourik, P.M., Lawrence, A.J., Paton, A.W., and Paton, J.C. (2013). Site of isolation determines biofilm formation and virulence phenotypes of serotype 3 Streptococcus pneumoniae clinical isolates. Infect. Immun. 81:505-513.
    • Paton, A.W., Wang, H., and Paton, J.C. (2013). BiP (Grp78): a target for Escherichia coli subtilase cytotoxin. Chapter 20, pp. 309-322. In: Henderson, B. (ed.). Moonlighting Cell Stress Proteins in Microbial Infections. Springer Science + Business Media B.V., Dordrecht, The Netherlands.
    • Wang, H., Paton, J.C., Herdman, B.P., Rogers, T.J., Beddoe, T., and Paton, A.W. (2013). The B subunit of an AB5 toxin produced by Salmonella enterica serovar Typhi up-regulates chemokines, cytokines and adhesion molecules in human macrophage, colonic epithelial and brain microvascular endothelial cell lines. Infect Immun. 81:673-683.
    • Paton, A.W., Wang, H., Michelacci, V., Morabito, S., and Paton, J.C. (2013). Escherichia coli subtilase cytotoxin: structure, function and role in disease. pp. 103-116. In: Morabito, S. (ed.). Pathogenic Escherichia coli: Molecular and Cellular Microbiology. Horizon Scientific Press, Norwich, UK.
    • Fruzangohar, M., Ebrahimie, E., Ogunniyi, A.D., Mahdi, L.K., Paton, J.C., and Adelson, D.L. (2013). Comparative GO: A web application for comparative gene ontology and gene ontology-based gene selection in bacteria. PLoS One. 8:e58759.
    • Heijmans, J., van Lidth de Jeude, J.F., Koo, B.K., Rosekrans, S.L., Wielenga, M.C.B., van de Wetering, M., Ferrante, M., Lee, A.S., Onderwater, J.J.M., Paton, J.C., Paton, A.W., Mommaas, A.M., Kodach, L.L., Hardwick, J.C., Hommes, D.W., Clevers, H., Muncan, V., and van den Brink, G.R. (2013). ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. Cell Reports 3: 1-12.
    • Gerhardt, E., Masso, M., Paton, A.W., Paton, J.C., Zotta, E., Ibarra, C. (2013). Inhibition of water absorption and selective damage to human colonic mucosa induced by Subtilase cytotoxin produced by Escherichia coli O113:H21. Infect. Immun. 81: 2931-2937.
    • Amaral, M.M., Sacerdoti, F., Jancic, C., Repetto, H.A., Paton, A.W., Paton, J.C., and Ibarra, C. (2013). Action of Shiga toxin type-2 and Subtilase cytotoxin on human microvascular endothelial cells. PLoS One. 8:e70431.
    • Mahdi, L.K., Ebrahimie, E., Adelson, D., Paton, J.C., and Ogunniyi, A.D. (2013). A transcriptional factor contributes to pathogenesis and virulence in Streptococcus pneumoniae. PLoS One. 8:e70862.
    • Plumptre, C.D., Ogunniyi, A.D., and Paton, J.C. (2013). Surface association of Pht proteins of Streptococcus pneumoniae. Infect. Immun. 81: 3644-3651.
    • Le Nours, J., Paton, A.W., Byres, E., Troy, S., Herdman, B.P., Johnson, M.D., Paton, J.C., Rossjohn, J., and Beddoe, T. (2013). Structural basis of subtilase cytotoxin SubAB assembly. J. Biol. Chem. 288: 27505-27516.
    • Ng, N., Littler, D., Le Nours, J., Paton, A.W., Paton, J.C., Rossjohn, J., and Beddoe, T. (2013). Cloning, expression, purification and preliminary x-ray diffraction studies of a novel AB5 toxin. Acta Cryst. F 69: 912-915.
    • Johnson, N., Haßdenteufel, S., Theis, M., Paton, A.W., Paton, J.C., Zimmermann, R., and High, S. (2013). The signal sequence influences post-translational ER translocation at distinct stages. PLoS One. 8: e75394.
    • Shak, J.R., Ludewick, H.P., Sakai, F., Harvey, R.M., Paton, J.C., Klugman, K.P., and Vidal, J.E. (2013). A novel role for the Streptococcus pneumoniae toxin pneumolysin in the assembly of biofilms. mBio. 4: e00655-13.
    • Ng, N.M., Littler, D.R., Paton, A.W., Le Nours, J., Paton, J.C., Smith, D.F., Rossjohn, J., and Beddoe, T. (2013). EcxAB is a founding member of a new family of metalloprotease AB5 toxins with a hybrid cholera-like B subunit. Structure. 21: 2003-2013.
    • Plumptre, C.D., Ogunniyi, A.D., and Paton, J.C. (2013). Vaccination against Streptococcus pneumoniae using truncated derivatives of polyhistidine triad protein D. PLoS One. 8: e78916.
    • Tikhomirova A., Kidd S.P. (2013). Haemophilus influenzae and Streptococcus pneumoniae: living together in a biofilm. Pathog Dis. 69:114-26
    • Ng J., Kidd S.P. (2013) The concentration of intracellular nickel in Haemophilus influenzae is linked to its surface properties and cell-cell aggregation and biofilm formation. Int J Med Microbiol. 303:150-7
    • Lum M., Attridge S.R., Morona R. (2013). Impact of dynasore an inhibitor of dynamin II on Shigella flexneri infection. PLoS One. 8:e84975.
    • George D.T., Stephenson D.P., Tran E., Morona R., Verma N.K. (2013) Complete Genome Sequence of SfII, a Serotype-Converting Bacteriophage of the Highly Prevalent Shigella flexneri Serotype 2a. Genome Announc. 1(5). pii: e00626-13. doi: 10.1128/genomeA.00626-13.
    • Tran E.N., Doyle M.T., Morona R. (2013). LPS unmasking of Shigella flexneri reveals preferential localisation of tagged outer membrane protease IcsP to septa and new poles. PLoS One. 8:e70508.
    • Morona R. (2013) Encapsulating bacteria. Structure. 21:692-3.
    • Teh M.Y., Morona R. (2013) Identification of Shigella flexneri IcsA residues affecting interaction with N-WASP, and evidence for IcsA-IcsA co-operative interaction. PLoS One. 8:e55152.
    • Tran E.N., Morona R. (2013). Residues located inside the Escherichia coli FepE protein oligomer are essential for lipopolysaccharide O-antigen modal chain length regulation. Microbiology. 159:701-14.
    • Standish A.J., Salim A.A., Capon R.J., Morona R. (2013). Dual inhibition of DNA polymerase PolC and protein tyrosine phosphatase CpsB uncovers a novel antibiotic target. Biochem Biophys Res Commun. 430:167-72.
  • 2012
    • Couñago R.L., McDevitt C.A., Ween M.P., Kobe B. (2012) Prokaryotic substrate-binding proteins as targets for antimicrobial therapies. Current Drug Targets 3:1400-10 [pdf]
    • Lewis, V.G., Ween, M.P., and McDevitt C.A. (2012) The role of ATP-binding cassette transporters in bacterial pathogenicity. Protoplasma. 249:919-942 [pdf]
    • Lehane, A.M., McDevitt, C.A., Kirk, K., and Fidock, D.A. (2012) Degrees of chloroquine resistance in Plasmodium - is the redox system involved? Int. J. Paras. Drugs Drug Res. 1:47-57 [pdf]
    • Ogunniyi, A.D., and Paton, J.C. (2012). Regulation of pneumococcal surface proteins and capsule. pp. 190-208. In: Vasil, M.L., and Darwin, A.J. (eds.). Regulation of Bacterial Virulence. ASM Press, Washington, DC.
    • McAllister, L.J., Ogunniyi, A.D., Stroeher, U.H., and Paton, J.C. (2012). Contribution of a genomic accessory region encoding a putative cellobiose phosphotransferase system to virulence of Streptococcus pneumoniae. PLoS One. 7:e32385.
    • Weber, M., Lambeck, S., Ding, S., Henken, S., Kohl, M., Deigner, H.P., Enot, D.P., Igwe, E.I., Frappart, L., Kiehntopf, M., Claus, R.A., Kamradt, T., Weih, D., Vodovotz, Y., Briles, D.E., Ogunniyi, A.D., Paton, J.C., Maus, U.A., and Bauer, M. (2012). Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia. FASEB J. 26:2424-2436.
    • Mahdi, L.K., Wang, H., Van der Hoek, M.B., Paton, J.C., and Ogunniyi, A.D. (2012). Identification of a novel pneumococcal vaccine antigen preferentially expressed during meningitis in mice. J. Clin. Invest. 122:2208-2220.
    • Paton, A.W., Morona, R., and Paton, J.C. (2012). Bioengineered microbes in disease therapy. Trends Mol. Med. 18:417-425.
    • Watts, R.E., Tan, C.K., Ulett, G.C., Carey, A.J., Idris, A., Totsika, M., Paton, A.W., Morona, R., Paton, J.C. and Schembri, M.A. (2012). Escherichia coli 83972 expressing a P fimbriae oligosaccharide receptor mimic impairs adhesion of uropathogenic E. coli. J. Infect. Dis. 206:1242-1249.
    • Schäuble, N., Lang, S., Jung, M., Cappel, S., Schorr, S., Ulukan, O., Linxweiler, J., Dudek, J., Blum, R., Helms, V., Paton, A.W., Paton, J.C., Cavalié, A., and Zimmermann, R. (2012) BiP-mediated closing of the Sec61 channel via loop 7 interaction limits Ca2+ leakage from the ER. EMBO J. 31: 3282-3296.
    • Rogers, T.J., Thorpe, C.M., Paton, A.W., and Paton, J.C. (2012). Role of lipid rafts and flagellin in invasion of colonic epithelial cells by Shiga toxigenic Escherichia coli O113:H21. Infect. Immun. 80: 2858-2867.
    • Plumptre, C.D., Ogunniyi, A.D., and Paton, J.C. (2012). Poly-histidine triad proteins of pathogenic streptococci. Trends Microbiol. 20: 485-493.
    • Eletto, D., Maganty, A., Eletto, D., Dersh, D., Makarewich, C., Biswas, C., Paton. J.C., Paton, A.W., Doroudgar, S., Glembotski, C.C., and Argon, Y. (2012). Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response. J. Cell Sci. 125: 4865-4875.
    • Ogunniyi, A.D., Mahdi, L.K., Trappetti, C., Verhoeven, N., Mermans, D., Van der Hoek, M., Plumptre, C., and Paton, J.C. (2012). Identification of genes that contribute to pathogenesis of invasive pneumococcal disease by in vivo transcriptomic analysis. Infect. Immun. 80:3268-3278.
    • Athanasiou, D., Kosmaoglou, M., Kanuga, N., Novoselov, S.S., Paton, A.W., Paton, J.C., Chapple, J.P., and Cheetham, M.E. (2012). BiP prevents rod opsin aggregation. Mol. Biol. Cell. 23:3522-3531.
    • Ray, R., de Ridder, G.G., Eu, J.P., Paton, A.W., Paton, J.C., and Pizzo, S.V. (2012). The Escherichia coli subtilase cytotoxin A subunit specifically cleaves cell-surface GRP78 and abolishes COOH-terminal-dependent signalling. J. Biol. Chem. 287:32755-32769.
    • Johno, H., Nakajima, S., Kato, H., Yao, F., Paton, A.W., Paton, J.C., Katoh, R., Shimizu, F., and Kitamura, M. (2012). Unfolded protein response causes a phenotypic shift of inflamed glomerular cells towards redifferentiation through dual blockade of Akt and Smad signaling pathways. Am. J. Path. 181:1977-1990.
    • Potter, A.J., Trappetti, C., and Paton, J.C. (2012). Streptococcus pneumoniae uses glutathione to defend against oxidative stress and metal ion toxicity. J. Bacteriol. 194:6248-6254.
    • Brumshagen, C., Maus, R., Bischof, A., Ueberberg, B., Bohling, J., Osterholzer, J., Ogunniyi, A.D., Paton, J.C., Welte, T., and Maus, U.A. (2012). FMS-like tyrosine kinase-3 ligand (Flt3L) treatment of mice aggravates acute lung injury in response to Streptococcus pneumoniae: role of pneumolysin. Infect. Immun. 80:4281-4290.
    • Kidd S.P., Jiang D., Tikhomirova A., Jennings M.P., McEwan A.G. (2012) A glutathione-based system for defense against carbonyl stress in Haemophilus influenzae. BMC Microbiol. doi: 10.1186/1471-2180-12-159.
    • Djoko K.Y., Franiek J.A., Edwards J.L., Falsetta M.L., Kidd S.P., Potter A.J., Chen N.H., Apicella M.A., Jennings M.P., McEwan A.G. (2012) Phenotypic characterization of a copA mutant of Neisseria gonorrhoeae identifies a link between copper and nitrosative stress. Infect Immun. 80:1065-71.
    • Teh M.Y., Tran E.N., Morona R. (2012). Absence of O antigen suppresses Shigella flexneri IcsA autochaperone region mutations. Microbiology. 158:2835-50.
    • Ericsson D.J., Standish A., Kobe B., Morona R. (2012) Wzy-dependent bacterial capsules as potential drug targets. Curr Drug Targets. 13:1421-31.
    • Standish A.J., Salim A.A., Zhang H., Capon R.J., Morona R. (2012). Chemical inhibition of bacterial protein tyrosine phosphatase suppresses capsule production. PLoS One. 7:e36312.
    • May K.L., Grabowicz M., Polyak S.W., Morona R. (2012). Self-association of the Shigella flexneri IcsA autotransporter protein. Microbiology. 158:1874-83.
    • Zvarec O., Polyak S.W., Tieu W., Kuan K., Dai H., Pedersen D.S., Morona R., Zhang L., Booker G.W., Abell A.D. (2012). 5-benzylidenerhodanine and 5-benzylidene-2-4-thiazolidinedione based antibacterials. Bioorg Med Chem Lett. 22:2720-2.
    • Soares da Costa T.P., Tieu W., Yap M.Y., Pendini N.R., Polyak S.W., Sejer Pedersen D., Morona R., Turnidge J.D., Wallace J.C., Wilce M.C., Booker G.W., Abell A.D. (2012). Selective inhibition of biotin protein ligase from Staphylococcus aureus. J Biol Chem. 287:17823-32.
    • Lum M., Morona R. (2012). IcsA autotransporter passenger promotes increased fusion protein expression on the cell surface. Microb Cell Fact. 11:20. doi: 10.1186/1475-2859-11-20.
  • 2011
    • Kadioglu, A., A.M. Cuppone, C. Trappetti, T. List, A. Spreafico, G. Pozzi, P.W. Andrew, M.R. Oggioni. (2011). Sex based differences in susceptibility to respiratory and systemic pneumococcal disease in mice. J. Infect. Dis. 204:1971-1979.
    • Trappetti C, Gualdi L, Di Meola L, Jain P, Korir CC, Edmonds P, Iannelli F, Ricci S, Pozzi G, Oggioni MR. (2011). The impact of the competence quorum sensing system on Streptococcus pneumoniae biofilms varies depending on the experimental model. BMC Microbiol. 11:75. 
    • McEwan AG, Djoko KY, Chen NH, Couñago RL, Kidd SP, Potter AJ, Jennings MP. (2011). Novel bacterial MerR-like regulators their role in the response to carbonyl and nitrosative stress. Adv Microb Physiol. 58:1-22.
    • Kidd SP. Editor Stress Responses in Pathogenic Bacteria, CABI Press, London. July 2011.
    • Kidd SP. (2011). Novel regulators in pathogenic bacteria; The MerR family of transcription factors. In Stress Responses in Pathogenic Bacteria (ed. Stephen P. Kidd), CABI Press, London. July 2011.
    • Kidd SP, Djoko KY, Ng J, Argente MP, Jennings MP, McEwan AG. (2011). A novel nickel responsive MerR-like regulator, NimR, from Haemophilus influenzae. Metallomics. 3:1009-1018. 
    • McDevitt, C.A., Ogunniyi, A.D., Valkov, E., Lawrence, M.C., Kobe, B., McEwan, A.G., and Paton, J.C. (2011). A molecular mechanism for bacterial susceptibility to zinc. PLoS Pathogens. 7(11):e1002357. 
    • Hahn, I., Klaus, A., Janze, A.K., Steinwede, K., Ding, N., Bohling, J., Brumshagen, C., Serrano, H., Gauthier, F., Paton, J.C., Welte, T., and Maus, U.A. (2011). Cathepsin G and neutrophil elastase play critical and non-redundant roles in lung protective immunity against Streptococcus pneumoniae in mice. Infect. Immun. 79:4893-4901. 
    • Steinwede, K., Tempelhof, O., Bolte, K., Maus, R., Bohling, J., Ueberberg, B., Länger, F., Christman, J.W., Paton, J.C., Ask, K., Maharaj, S., Kolb, M., Gauldie, J., Welte, T., and Maus, U.A. (2011). Local delivery of GM-CSF protects mice from lethal pneumococcal pneumonia. J. Immunol. 187:5346-5356. 
    • McAllister, L.J., Ogunniyi, A.D., Stroeher, U.H., Leach, A.J., and Paton, J.C. (2011). Contribution of serotype and genetic background to virulence of Serotype 3 and Serogroup 11 pneumococcal isolates. Infect. Immun. 79: 4839-4849. 
    • Trappetti, C., Potter, A.J., Paton, A.W., Oggioni, M.R., and Paton, J.C. (2011). LuxS mediates iron-dependent biofilm formation, competence and fratricide in Streptococcus pneumoniae. Infect. Immun. 79: 4550-4558.
    • Harvey, R.M., Ogunniyi, A.D., Chen, A.Y., and Paton, J.C. (2011). Pneumolysin with low hemolytic activity confers an early growth advantage to Streptococcus pneumoniae in the blood. Infect. Immun. 79:4122-4130.
    • Zhang, H., Zhao, T., Tian, T., Paton, A.W., Paton, J.C., and Kitamura, M. (2011). Oscillation of mitogen-activated protein kinases in response to endoplasmic reticulum stress. Anal. Biochem. 417:292-294.
    • Tian, T., Zhao, Y., Nakajima, S., Huang, T., Yao, J., Paton, A.W., Paton, J.C., and Kitamura, M. (2011). Cytoprotective roles of ERK and Akt in endoplasmic reticulum stress triggered by subtilase cytotoxin. Biochem. Biophys. Res. Commun. 410: 852-858.
    • Goodwin, E.C., Lipovsky, A., Inoue, T., Magaldi, T.G., Edwards, A.P.B., Van Goor, K.E.Y., Paton, A.W., Paton, J.C., Atwood, W.J., Tsai, B., and DiMaio, D. (2011). BiP and multiple DNAJ molecular chaperones in the endoplasmic reticulum are required for efficient SV40 infection. mBio. 2: e00101-11.
    • Lammerts van Bueren, A., Ficko-Blean, E., Pluvinage, B., Hehemann, J.H., Higgins, M.A., Deng, L., Ogunniyi, A.D., Stroeher, U.H., El Warry, N., Burke, R.D., Czjzek, M., Paton, J.C., Vocadlo, D.J., and Boraston, A.B. (2011). The conformation and function of a multimodular glycogen-degrading pneumococcal virulence factor. Structure. 19: 640-651.
    • Harvey, R.M., Stroeher, U.H., Ogunniyi, A.D., Smith-Vaughan, H., Leach, A., and Paton, J.C. (2011). A variable region within the genome of Streptococcus pneumoniae contributes to strain-strain variation in virulence. PLoS One. 6: e19650.
    • Trappetti, C., Ogunniyi, A.D., Oggioni, M., and Paton, J.C. (2011). Extracellular matrix formation enhances the ability of Streptococcus pneumoniae to cause invasive disease. PLoS One. 6: e19844.
    • Coats, M.T, Murphy, T., Paton, J.C., Gray, B., and Briles, D.E. (2011). Exposure of Thomsen-Friedenreich antigen in Streptococcus pneumoniae infection is dependent on pneumococcal neuraminidase A. Microb. Pathog. 50: 343-349. [IF 2.32]
    • Byrne, J.P., Morona, J.K., Paton, J.C., and Morona, R. (2011). Identification of Streptococcus pneumoniae Cps2C residues that affect capsular polysaccharide polymerisation, cell wall ligation and Cps2D phosphorylation. J. Bacteriol. 193: 2341-2346. [IF 3.94]
    • Cox, D., Strudwick, N., Ali, A.A., Paton, A.W., Paton, J.C., and Schröder, M. (2011). Measuring signaling by the unfolded protein response. Methods Enzymol. 491: 261-292. [IF 1.9]
    • Paton, J.C., and Ogunniyi, A.D. (2011). Evicting the pneumococcus from its nasopharyngeal lodgings. Cell Host & Microbe. 9: 89-91.
    • Nakajima, S., Hiramatsu, N., Hayakawa, K., Saito, Y., Huang, T., Yao, J., Paton, A.W., Paton, J.C., and Kitamura, M. (2011). Selective abrogation of BiP/GRP78 blunts activation of NF-κB through the ATF6 branch of the UPR: involvement of C/EBPβ and mTOR-dependent dephosphorylation of Akt. Mol. Cell. Biol. 31: 1710-1718.
    • Wang, H., Paton, A.W., McColl, S.R., and Paton, J.C. (2011). In vivo leukocyte changes induced by Escherichia coli subtilase cytotoxin. Infect. Immun. 79: 1671-1679.
    • Zhao, Y., Tian, T., Huang, T., Nakajima, S., Saito, Y., Takahashi, S., Yao, J., Paton, A.W., Paton, J.C., and Kitamura, M. (2011). Subtilase cytotoxin activates MAP kinases through PERK and IRE1 branches of the unfolded protein response. Toxicol. Sci. 120:79-86.
    • Paton, A.W., Morona, R., and Paton, J.C. (2011). Designer probiotics and enteric cytoprotection. pp. 429-443. In: Malago, J.J., Koninkx, J.F.J.G., and Marinsek-Logar, R. (eds.), Probiotic Bacteria and Enteric Infections. Springer-Verlag, Netherlands.
    • Kidd S.P., Djoko K.Y., Ng J., Argente M.P., Jennings M.P., McEwan A.G. (2011). A novel nickel responsive MerR-like regulator, NimR, from Haemophilus influenzae. Metallomics. 3:1009-18.
    • McEwan A.G., Djoko K.Y., Chen N.H., Couñago R.L., Kidd S.P., Potter A.J., Jennings M.P. (2011). Novel bacterial MerR-like regulators their role in the response to carbonyl and nitrosative stress. Adv Microb Physiol. 58:1-22.
  • 2010
    • Wu HJ, Seib KL, Srikhanta YN, Edwards J, Kidd SP, Maguire TL, Hamilton A, Pan KT, Hsiao HH, Yao CW, Grimmond SM, Apicella MA, McEwan AG, Wang AH, Jennings MP. (2010). Manganese regulation of virulence factors and oxidative stress resistance in Neisseria gonorrhoeae. J. Proteomics. 73: 899-916. 
    • Pidot SJ, Porter JL, Tobias NJ, Anderson J, Catmull D, Seemann T, Kidd S, Davies JK, Reynolds E, Dashper S, Stinear TP. (2010). Regulation of the 18 kDa heat shock protein in Mycobacterium ulcerans: crystallin orthologue that promotes biofilm formation. Mol. Microbiol. 78:1216-31.
    • May, K.L., Paton, J.C., and Paton, A.W. (2010). Escherichia coli subtilase cytotoxin induces apoptosis regulated by host Bcl-2 family proteins, Bax/Bak. Infect. Immun. 78: 4691-4696. 
    • Martin, S., Hill, D.S., Paton, J.C., Paton, A.W., Birch-Machin, M.A., Lovat, P.E., and Redfern, C.P.F. (2010). Targeting GRP78 to enhance melanoma cell death. Pigment Cell & Melanoma Res. 23: 675-682. 
    • Ogunniyi, A.D., Mahdi, L.K., Jennings, M.P., McEwan, A.G., McDevitt, C.A., Van der Hoek, M.B., Bagley, C.J., Hoffmann, P., Gould, K.A., and Paton, J.C. (2010). Central role of manganese in regulation of stress responses, physiology and metabolism in Streptococcus pneumoniae. J. Bacteriol. 192: 4489-4497. 
    • Henken, S., Bohling, J., Ogunniyi, A.D., Paton, J.C., Salisbury, V.C., Welte, T., and Maus, U.A. (2010). Evaluation of biophotonic imaging to estimate bacterial burden in mice infected with highly virulent compared to less virulent Streptococcus pneumonia serotypes. Antimicrob. Agents Chemother. 54: 3155-3160. 
    • Wang, H., Paton, J.C., Thorpe, C.M., Bonder, C.S., Sun, W.Y., and Paton, A.W. (2010). Tissue factor-dependent procoagulant activity of subtilase cytotoxin, a potent AB5 toxin produced by Shiga toxigenic Escherichia coli. J. Infect. Dis. 202: 1415-1423.
    • Potter, A.J., Kidd, S.P., McEwan, A.G., and Paton, J.C. (2010). The MerR/NmlR family transcription factor of Streptococcus pneumoniae responds to carbonyl stress and modulates hydrogen peroxide production. J. Bacteriol. 192: 4063-4066.
    • Nakajima, S., Saito,Y., Takahashi, S., Hiramatsu, N., Kato, H., Johno, H., Yao, J., Paton, A.W., Paton, J.C., and Kitamura, M. (2010). Anti-inflammatory subtilase cytotoxin up-regulates A20 through the unfolded protein response. Biochem. Biophys. Res. Commun. 397: 176-180.
    • Paton, A.W., Morona, R., and Paton, J.C. (2010). Receptor-mimic probiotics: potential therapeutics for bacterial toxin-mediated enteric diseases. Expert Rev. Gastroenterol. Hepatol. 4: 253-255.
    • Jandhyala, D.M., Rogers, T.J., Kane, A., Paton, A.W., Paton, J.C., and Thorpe, C.M. (2010). Shiga toxin 2 and flagellin from Shiga toxigenic Escherichia coli super-induce IL-8 through synergistic effects on host SAPKinase activation. Infect Immun. 78: 2984-2994. 
    • Paton, J.C. (2010). Vaccines against Streptococcus pneumoniae. pp. 303-328. In: Rappuoli, R., Bagnoli, F. (eds). Vaccine Design: Innovative Approaches and Novel Strategies. Horizon Scientific Press, Norwich, UK.
    • Herbold, W., Maus, R., Hahn, I., Ding, N., Srivastava, M., Christman, J.W., Mack, M., Reutershan, J., Briles, D.E., Paton, J.C., Winter, C., Welte, T., and Maus, U.A. (2010). Importance of CXC chemokine receptor 2 in neutrophil and exudate macrophage recruitment in response to pneumococcal lung infection. Infect. Immun. 78: 2620-2630.
    • Beddoe, T., Paton, A.W., Le Nours, J., Rossjohn, J., and Paton, J.C. (2010) Structure, biological functions and applications of the AB5 toxins. Trends Biochem. Sci. 35: 411-418. 
    • Zhang, Q., Bagrade, L., Clarke, E., Paton, J.C., Nunez, D.A., and Finn, A. (2010). Bacterial lipoproteins differentially regulate human primary and memory CD4+ T and B cell responses to pneumococcal protein antigens through TLR2. J. Infect. Dis. 201: 1753-1763. 
    • Paton, A.W., and Paton, J.C. (2010). Escherichia coli subtilase cytotoxin. Toxins 2: 215-228.
    • Paton, A.W., Morona, R., and Paton, J.C. (2010). Bioengineered bugs expressing oligosaccharide receptor mimics: toxin-binding probiotics for treatment and prevention of enteric infections. Bioengineered Bugs 1: 172-177. 
    • Henken, S., Bohling, J., Martens-Lobenhoffer, J., Paton, J.C., Ogunniyi, A.D., Briles, D.E., Salisbury, V.C., Wedekind, D., Bode-Böger, S.M., Welsh, T., Bange, F., Welte, T., and Maus, U.A. (2010). Efficacy profile of daptomycin for the treatment of invasive as compared to non-invasive pulmonary infections with S. pneumoniae. Antimicrob. Agents Chemother. 54:707-717. 
    • Papadopoulos, M. and Morona, R. (2010) Mutagenesis and chemical cross-linking suggest that Wzz dimer stability and oligomerization affect lipopolysaccharide O-antigen modal chain length control. J. Bacteriol. 192: 3385-3393.
    • Wu H.J., Seib K.L., Srikhanta Y.N., Edwards J., Kidd S.P., Maguire T.L., Hamilton A., Pan K.T., Hsiao H.H., Yao C.W., Grimmond S.M., Apicella M.A., McEwan A.G., Wang A.H., Jennings M.P. (2010). J Proteomics. 2010 73:899-916.
  • 2009
    • Trappetti C, A. Kadioglu, M. Carter, J. Hayre, F.Iannelli, G.Pozzi, P.W. Andrew, M.R.Oggioni. (2009). Sialic acid: A preventable signal for pneumococcal biofilm formation, colonization and invasion of the host. J. Infect. Dis. 199: 1497-1505.
    • Wati, S., Soo, M-L., Zilm, P., Li, P., Paton, A.W., Burrell, C.J., Beard, M., and Carr, J.M. (2009). Dengue virus infection induces GRP78 which acts to chaperone viral antigen production. J. Virol. 83: 12871-12880.
    • Potter AJ, Kidd SP, Edwards JL, Falsetta ML, Apicella MA, Jennings MP, McEwan AG. (2009). Esterase D is essential for protection of Neisseria gonorrhoeae against nitrosative stress and for bacterial growth during interaction with cervical epithelial cells. J. Infect. Dis. 200: 273-278.
    • Wati, S., Soo, M-L., Zilm, P., Li, P, Paton, A.W., Burrell, C.J., Beard, M., and Carr, J. M. (2009). Dengue virus infection induces GRP78 which acts to chaperone viral antigen production. J. Virol. 83: 12871-12880.
    • Buchkovich, N.J., Maguire, T.G., Paton, A.W., Paton, J.C., and Alwine, J.C. (2009). The endoplasmic reticulum chaperone BiP/GRP78 is important in the structure and function of the HCMV assembly compartment. J. Virol. 83: 11421-11428. 
    • Hu, C.A., Dougan, S.K., Winter, S.V., Paton, A.W., Paton, J.C., and Ploegh, H.L. (2009). Subtilase cytotoxin cleaves newly synthesised BiP and blocks antibody secretion in B lymphocytes. J. Exp. Med. 206: 2429-2440. 
    • Herold, S., Paton, J.C., Srimanote, P., and Paton, A.W. (2009). Differential effects of short chain fatty acids and iron on expression of iha in Shiga toxigenic Escherichia coli. Microbiology. 155: 3554-3563. 
    • Smith, R.D., Willett, R., Kudlyk, T., Pokrovskaya, I., Paton, A.W., Paton, J.C., and Lupashin, V.V. (2009). The COG comples, Rab6 and COPI define a novel Golgi retrograde trafficking pathway that is exploited by SubAB toxin. Traffic 10: 1502-1517. 
    • Backer, J.M., Krivoshein, A., Hamby, C.V., Pizzonia, J., Gilbert, K., Ray, Y.S., Brand, H., Paton, A.W., Paton, J.C., and Backer, M.V. (2009). Chaperone-targeting cytotoxin and ER stress-inducing drug synergize to kill cancer cells. Neoplasia 11: 1165-1173. 
    • Rogers, T.J., and Paton, J.C. (2009). Therapeutic strategies for Shiga toxin-producing Escherichia coli infections. Expert Rev. Anti Infect. Ther. 7: 683-686.
    • Martner, A., Skovbjerg, S., Paton, J.C., and Wold, A.E. (2009). Streptococcus pneumoniae autolysis prevents phagocytosis and production of phagocyte activating cytokines. Infect. Immun. 77: 3826-3837. 
    • Huang, T., Wan, Y., Zhu, Y., Fang, X., Hiramatsu, N., Hayakawa, K., Paton, A.W., Paton, J.C., Kitamura, M, and Yao, J. (2009). Downregulation of gap junction expression and function by endoplasmic reticulum stress. J. Cell Biochem. 107: 973-983. 
    • Yamazaki, H., Hiramatsu, N., Hayakawa, K., Okamura, M., Huang, T., Nakajima, S., Yao, J., Paton, A.W., Paton, J.C., and Kitamura, M. (2009). Activation of the Akt - NF-κB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response. J. Immunol. 183: 1480-1487. 
    • Herold, S., Paton, J.C., and Paton, A.W. (2009). Sab, a novel autotransporter of locus of enterocyte effacement-negative Shiga toxigenic Escherichia coli O113:H21, contributes to adherence and biofilm formation. Infect. Immun. 77: 3234-3243. 
    • Harama, D., Koyama, K., Mukai, M., Shimokawa, N., Miyata, M., Nakamura, Y., Ohnuma, Y., Ogawa, H., Matsuoka, S., Paton, A.W., Paton, J.C., Kitamura, M., and Nakao, A. (2009). A sub-cytotoxic dose of subtilase cytotoxin prevents LPS-induced inflammatory responses, depending on its capacity to induce the unfolded protein response. J. Immunol. 183: 1368-1374. 
    • Du, S., Hiramatsu, N., Hayakawa, K., Kasai, A., Okamura, M., Huang, T., Yao, J., Takeda, M., Araki, I., Sawada, N., Paton, A.W., Paton, J.C., and Kitamura, M. (2009). Suppression of NF-κB by cyclosporin A and tacrolimus (FK506) via induction of the C/EBP family: Implication for unfolded protein response. J. Immunol. 182:7201-7211. 
    • Löfling, J.C., Paton, A.W., Varki, N.M., Paton, J.C., and Varki, A. (2009). A dietary non-human sialic acid may faciliate hemolytic-uremic syndrome. Kidney Int. 76: 140-144. 
    • Winter, C., Herbold, W., Maus, R., Langer, F., Briles, D.E., Paton, J.C., Welte, T., and Maus, U.A. (2009). Important role for CC chemokine ligand 2-dependent lung mononuclear phagocyte recruitment to inhibit sepsis in mice infected with Streptococcus pneumoniae. J. Immunol. 182: 4931-4937. 
    • Arévalo, M.T., Xu, Q., Paton, J.C., Hollingshead, S.K., Pichichero, M.E., Briles, D.E., and Zeng, M. (2009). Mucosal vaccination with a multi-component adenovirus-vectored vaccine protects against Streptococcus pneumoniae colonization in the lung. FEMS Immunol. Med. Microbiol. 55:346-351. 
    • Newton, H.J., Sloan, J., Bulach, D.M., Seemann, T., Allison, C., Tauschek, M., Robins-Browne, R.M., Paton, J.C., Whittam, T.S., Paton, A.W., and Hartland, E.L. (2009). Shiga toxin-producing Escherichia coli strains negative for locus of enterocyte effacement. Emerg. Infect. Dis. 15: 372-380. 
    • Briles, D.E., Paton, J.C., Hollingshead, S.K, and Boslego, J.W. (2009). Pneumococcal common proteins and other vaccine strategies. pp. 908-933. In: M.M. Levine, J.B. Kaper, R. Rappuoli, M. Liu, and M.F. Good (eds.). New Generation Vaccines (4th Edition). Marcel Dekker, New York, USA.
    • Paton, A.W., and Paton, J.C. (2009). Subtilase cytotoxin - a new bacterial AB5 cytotoxin family. pp. 81-89. In: Proft, T. (ed.). Microbial Toxins: Current Research and Future Trends, Horizon Scientific Press, Norwich, UK. 
    • Ogunniyi, A.D., Grabowicz, M., Mahdi, L.K., Cook, J., Gordon, D.L., Sadlon, T.A., and Paton, J.C. (2009). Pneumococcal histidine triad proteins are regulated by the Zn2+-dependent repressor AdcR and inhibit complement deposition through the recruitment of complement factor H. FASEB J. 23:731-738. 
    • Hayakawa, K., Hiramatsu, N., Okamura, M., Yamazaki, H., Nakajima, S., Yao, J., Paton, A.W., Paton, J.C., and Kitamura, M. (2009). Acquisition of anergy to proinflammatory cytokines in non-immune cells through endoplasmic reticulum stress response: a mechanism for subsidence of inflammation. J. Immunol. 182:1182-1191. 
    • Morona, R., Purins, L., Tocilj, A., Matte, A., and Cygler M. (2009) Sequence-structure relationships in polysaccharide co-polymerase (PCP) proteins. Trends Biochem Sci. 34:78-84.
    • Attridge, S.R, Wallerström G, Li, B.L., Morona, R., and Holmgren J. (2009) Differential immunogenicity of Vibrio cholerae O139 variants expressing different combinations of naturally occurring and atypical forms of the serogroup polysaccharide. Vaccine 27:1055-1061.
  • 2008
    • May, K.M. and Morona, R. (2008) Mutagenesis of the Shigella flexneri autotransporter IcsA reveals novel functional regions involved in IcsA biogenesis and recruitment of host neural Wiscott-Aldrich syndrome protein. J. Bacteriol. 190:4666-4676.
    • Purins, L., Van Den Bosch, L., and Richardson, V., and Morona, R., (2008) Coiled-coil regions play a role in the function of the Shigella flexneri O-antigen chain length regulator WzzpHS2. Microbiology 154:1104-1116.
    • Tocilj, A., Munger, C., Proteau, A., Morona, R., Purins, L., Ajamina, E., Wagner, J., Papadopoulos, M., Van Den Bosch, L., Rubinstein, J.L., Féthière, J., Matte, A., and Cygler, M. (2008) Bacterial polysaccharide co-polymerases share a common framework for control of polymer length. Nature Struct. Mol. Biol. 15:130-138.
    • Paton, J.C. and Boslego, J.W. (2008). Protein Vaccines. Chapter 28. In: Siber, G.R., Klugman, K.P., and Makela, P.H. (eds). Pneumococcal Vaccines: the Impact of Conjugate Vaccines. ASM Press, Washington DC, USA. ISBN: 978-1-55581-408-3.
    • Chen, Q., Cannons, J., Paton, J.C., Akiba, H., Schwartzberg, P.L., and Snapper, C.M. (2008). A novel ICOS-independent, but CD28- and SAP-dependent, pathway of T cell-dependent, polysaccharide-specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococcal conjugate vaccine. J. Immunol. 181: 8258-8266. 
    • Okamura, M., Takano, Y., Hiramatsu, N., Hayakawa, K., Yao, J., Paton, A.W., Paton, J.C., and Kitamura, M. (2008). Suppression of cytokine responses by indomethacin in podocytes: a mechanism through induction of unfolded protein response. Am. J. Physiol. Renal Physiol. 295: F1495-1503. 
    • Byres, E., Paton, A.W., Paton, J.C., Löfling, J.C., Smith, D.F., Wilce, M.C.J., Talbot, U.M., Chong, D.C., Yu, H., Huang, S., Chen, X., Varki, N.M., Varki, A., Rossjohn, J., and Beddoe, T. (2008). Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin. Nature. 456: 648-652. 
    • Bernatoniene, J., Zhang, Q., Dogan, S., Mitchell, T.J., Paton, J.C., and Finn, A. (2008). Induction of CC and CXC chemokines in human antigen presenting (dendritic) cells by pneumococcal proteins pneumolysin and CbpA: the role of TLR4, NFκB and MAPKinases. J. Infect. Dis. 198:1823-1833. 
    • Ogunniyi, A.D., Paton, J.C., Kirby, A.C., McCullers, J.A., Cook, J., Hyodo, M., Hayakawa, Y., and Karaolis, D.K.R. (2008). c-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection. Vaccine. 26:4676-4685. 
    • Lass, A., Kujawa, M., McConnell, E., Paton, A.W., Paton, J.C., and Wójcik, C. (2008). Decreased ER-associated degradation of α-TCR induced by Grp78 depletion with the SubAB cytotoxin. Int. J.Biochem. Cell Biol. 40: 2865-2879. 
    • Martner, A., Dahlgren, C., Paton, J.C., and Wold, A.E. (2008). Pneumolysin released during Streptococcus pneumoniae autolysis is a potent activator of intracellular oxygen radical production in neutrophils. Infect Immun. 76: 4079-4087. 
    • Takano, S., Ando, T., Hiramatsu, N., Kanayama, A., Maekawa, S., Ohnuma, Y., Enomoto, N., Ogawa, H., Paton, A.W., Paton, J.C., Kitamura, M., and Nakao, A. (2008). T cell receptor-mediated signaling induces GRP78 expression in T-cells: the implications in maintaining T cell viability. Biochem. Biophys. Res. Commun. 371: 762-766. 
    • Wolfson, J., Thorpe, C.M., May, K.L., Paton, J.C., Jandhyala, D.M., and Paton, A.W. (2008). Subtilase cytotoxin activates PERK, ATF6 and IRE1 endoplasmic reticulum stress-signaling pathways. Cell. Microbiol. 10: 1775-1786. 
    • Kadioglu, A., Weiser, J.N., Paton, J.C., and Andrew, P.W. (2008). The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease. Nature Rev. Microbiol. 6: 288-301. 
    • Mahdi. L.K., Ogunniyi, A.D., LeMessurier, K.S., and Paton, J.C. (2008). Pneumococcal virulence gene expression and host cytokine profiles during pathogenesis of invasive disease. Infect. Immun. 76: 646-657. 
    • Chong, D.C., Paton, J.C., Thorpe, C.M., and Paton, A.W. (2008). Clathrin-dependent trafficking of subtilase cytotoxin, a novel AB5 toxin that targets the endoplasmic reticulum chaperone BiP. Cell. Microbiol. 10: 795-806. 
    • Hayakawa, K., Hiramatsu, N., Okamura, M., Yao, J., Paton, A.W., Paton, J.C., and Kitamura, M. (2008). Blunted activation of NF-κB and NF-κB-dependent gene expression by geranylgeranylacetone: Involvement of unfolded protein response. Biochem. Biophys. Res. Comm. 365: 47-53. 
    • Buchkovich, N.J., Maguire, T.G., Yu, Y., Paton, A.W., Paton, J.C., and Alwine, J.C. (2008). Human Cytomegalovirus specifically controls the levels of the endoplasmic reticulum chaperone BiP/GRP78, which is required for virion assembly. J. Virol. 82: 31-39.
    • Taut, K., Winter, C., Briles, D.E., Paton, J.C., Christman, J.W., Maus, R., Baumann, T., Welte, T., and Maus, U.A. (2008). Macrophage turnover kinetics in the lungs of mice infected with Streptococcus pneumoniae. Am J. Resp. Cell Mol. Biol. 38:105-113.
    • Dessing, M.C., Florquin, S., Paton, J.C., and van der Poll, T. (2008). Toll-like receptor 2 contributes to antibacterial defense against pneumolysin-deficient pneumococci. Cell. Microbiol. 10:237-246.
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