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Scholarly Book Chapters

  • *Wright M, Grutzner F. Replication Timing: Evolution, Nuclear Organization and Relevance for Human Disease. In: DNA Replication-Current Advances, Ed Herve Seligmann, ISBN 978-953-307-593-8, In Tech, 2011
  • *Rowell DM, Lim SL, Grutzner F. Chromosome analysis in invertebrates and vertebrates. Methods Mol Biol. 772:13-35. 2011
  • Daish, T, Grützner F. Meiotic Sex Chromosome Inactivation, Encyclopedia of Life Sciences, John Wiley & Sons, Ltd. 2010
  • Grützner F. The platypus genome provides unique insights into early mammalian evolution and monotreme biology, Encyclopedia of Life Sciences, John Wiley & Sons, Ltd. 2009
  • Grützner F. Evolution and organization of monotreme sex chromosomes, Encyclopedia of Life Sciences, John Wiley & Sons, Ltd. 2009

Refereed Journal Articles

  • Necsulea A, Soumillon M, Warnefors M, Liechti A, Daish T, Zeller U, Baker JC, Grützner F, Kaessmann H. The evolution of lncRNA repertoires and expression patterns in tetrapods. Nature ;505(7485):635-40. 2014.
  • Lim SL, Tsend-Ayush E, Kortschak RD, Jacob R, Ricciardelli C, Oehler MK, Grützner F. Conservation and expression of PIWI-interacting RNA pathway genes in male and female adult gonad of amniotes. Biol Reprod. 12;89(6):136. 2013.
  • He C, Tsend-Ayush E, Myers MA, Forbes BE, Grützner F. Changes in the ghrelin hormone pathway maybe part of an unusual gastric system in monotremes. Gen Comp Endocrinol. ;191:74-82. 2013.
  • Chang CL, Semyonov J, Cheng PJ, Huang SY, Park JI, Tsai HJ, Lin CY, Grützner F, Soong YK, Cai JJ, Hsu SY. Widespread divergence of the CEACAM/PSG genes in vertebrates and humans suggests sensitivity to selection. PLoS One. ;8(4):e61701. 2013.
  • Ayers KL, Davidson NM, Demiyah D, Roeszler KN, Grützner F, Sinclair AH, Oshlack A, Smith CA. RNA sequencing reveals sexually dimorphic gene expression before gonadal differentiation in chicken and allows comprehensive annotation of the W-chromosome. Genome Biol. ;14(3):R26. 2013.
  • Long H, Sims A, Heger A, Blackledge NP, Kutter C, Wright ML, Grützner F, Odom DT, Patient R, Ponting CP, Klose RJ; Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates. ELife.00348. 2013.
  • Zemann A, Churakov G, Donellan S, Grützner F, Fangqing Z, Brosius J, Schmitz J. Ancestry of the Australian Termitivorous Numbat. Mol Biol Evol. Feb 21. [Epub ahead of print]. 2013.
  • Williams C, Hoppe HJ, Rezgui D, Strickland M, Forbes BE, Grutzner F, Frago S, Ellis RZ, Wattana-Amorn P, Prince SN, Zaccheo OJ, Nolan CM, Mungall AJ, Jones EY, Crump MP, Hassan AB. An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution. Science. 30;338(6111):1209-13. 2012.
  • Hrdliková R, Nehyba JI, Lim SL, Grützner F, Bose HR Jr. Insights into the evolution of mammalian telomerase: Platypus TERT shares similarities with genes of birds and other reptiles and localizes on sex chromosomes. BMC Genomics.13(1):216. 2012. IF 4.
  • Julien P, Brawand D, Soumillon M, Necsulea A, Liechti A, Schütz F, Daish T, Grützner F, Kaessmann H. Mechanisms and evolutionary patterns of mammalian and avian dosage compensation. PLoS Biol.10(5): e1001328. 2012.
  • Tsend-Ayush E, Kortschak RD, Bernard P, Lim SL, Ryan J, Rosenkranz R, Borodina T, Dohm JC, Himmelbauer H, Harley VR, Grützner F. Identification of mediator complex 26 (Crsp7) gametologs on platypus X1 and Y5 sex chromosomes: a candidate testis-determining gene in monotremes? Chromosome Res. 20(1):127-38. 2012. IF 3.
  • Brawand D, Soumillon M, Necsulea A, Julien P, Csárdi G, Harrigan P, Weier M, Liechti A, Aximu-Petri A, Kircher M, Albert FW, Zeller U, Khaitovich P, Grützner F, Bergmann S, Nielsen R, Pääbo S, Kaessmann H. The evolution of gene expression levels in mammalian organs. Nature. 19;478(7369):343-8. 2011.
  • Warren W, Grützner F. The enigma of the platypus genome. Australian Journal of Zoology ;57(4) 157–165. 2009.
  • Ho KK, Deakin JE, Wright ML, Graves JA, Grützner F. Replication asynchrony and differential condensation of X chromosomes in female platypus (Ornithorhynchus anatinus). Reprod Fertil Dev. 2009;21(8):952-63. 2009.
  • Tsend-Ayush E, Lim SL, Pask AJ, Hamdan DD, Renfree MB, Grützner F. Characterisation of ATRX, DMRT1, DMRT7 and WT1 in the platypus (Ornithorhynchus anatinus). Reprod Fertil Dev. 2009;21(8):985-91. 2009.
  • Daish T, Casey A and Grützner F, Platypus Chain Reaction: directional and ordered meiotic pairing of the multiple sex chromosome chain in Ornithorhynchus anatinus. Reprod Fertil Dev. 21(8):976-84. 2009. Cover.
  • *Kortschak D, Tsend-Ayush and Grützner F, Analysis of SINE and LINE repeat content of Y-chromosomes in the platypus, Ornithorhynchus anatinus. Reprod Fertil Dev. 2009;21(8):964-75. IF 2.4
  • Ivell R and Grützner F, Evolution and male fertility– lessons from the Insulin-like factor 6 gene (Insl6). Endocrinology 150(9):3986-90. 2009. IF 4.9.
  • Daish T, Grützner F. Location, location, location! Monotremes provide unique insights into the evolution of sex chromosome silencing in mammals. DNA Cell Biol.28(2):91-100. 2009. Invited Review.
  • Tsend-Ayush E, Dodge N, Mohr J, Casey A, Himmelbauer H, Kremitzki CL, Schatzkamer K, Graves T, Warren WC, Grützner F. Higher-order genome organization in platypus and chicken sperm and repositioning of sex chromosomes during mammalian evolution. Chromosoma. 2009. IF: 4.0
  • Niwa H, Sekita Y, Tsend-Ayush E, Grützner F. Platypus Pou5f1 reveals the first steps in the evolution of trophectoderm differentiation and pluripotency in mammals, Evolution & Development 10 (6), 671-682. 2008. IF: 3.7
  • Grützner F, Nixon B, Jones RC. Reproductive biology in egg-laying mammals. Sex Dev. 2(3):115-127. 2008.
  • Wakefield MJ, Anderson M, Chang E, Wei KJ, Kaul R, Graves JA, Grützner F, Deeb SS. Cone visual pigments of monotremes: filling the phylogenetic gap. Vis Neurosci. 25(3): 257-64. 2008.
  • Ordoñez G, Hillier LW, Warren WC, Grützner F, López-Otín C and Puente XS, (2008). Loss of genes implicated in gastric function during platypus evolution. Genome Biology  9(5):R81. IF: 6.9, ERA A
  • *Warren WC, Hillier LW, Marshall Graves JA,  Birney E, Ponting CP, Grützner F, Belov K, Miller W, et al. (together 85 authors) (2008). Genome analysis of the platypus reveals unique signatures of evolution, Nature, 453(7192):175-83. IF: 28.7, Faculty of 1000 recommendation: “exceptional”
  • Murchison E, Kheradpour P, Sachidanandam R, Smith C, Hodges E, Xuan Z, Kellis M, Grützner F, Stark A, and Hannon GJ (2008). miRNA and piRNA pathways in platypus and echidna. Genome Research, 18(6):995-1004. IF: 11.2
  • Schmitz J, Zemann A, Churakov G, Timmermann B, Grützner F, Reinhard R and Brosius J (2008). Retroposed SNOfall - A mammalian-wide comparative description of platypus snoRNAs, Genome Research, Jun;18(6):995-1004. IF: 11.2
  • *Veyrunes F, Waters P, Miethke P, Rens W, McMillan D, Alsop AE, Grützner F, Deakin JE, Whittington C, Schatzkamer K, Kremitzki CL, Graves T, Ferguson-Smith MA, Warren W, Marshall Graves JA (2008). Bird-like sex chromosomes of platypus imply recent origin of mammal sex chromosomes. Genome Research, 18(6):995-1004. IF: 11.2 Faculty of 1000 recommendation: “recommended”
  • McMillan D, Miethke P, Alsop AE, Rens W, O'Brien P, Trifonov V, Veyrunes F, Schatzkamer K, Kremitzki CL, Graves T, Warren W, Grützner F, Ferguson-Smith MA, Graves JA (2008). Characterizing the chromosomes of the platypus (Ornithorhynchus anatinus). Chromosome Res. 15(8):961-74. IF: 3.4
  • Wallis MC, Waters PD, Delbridge ML, Kirby PJ, Pask AJ, Grützner F, Rens W, Ferguson-Smith MA, Graves JA. (2008). Sex determination in platypus and echidna: autosomal location of SOX3 confirms the absence of SRY from monotremes. Chromosome Res. 15(8):949-59. Faculty of 1000 recommendation: “recommended”
  • Rens W, O'Brien PC, Grützner F, Clarke O, Graphodatskaya D, Tsend-Ayush E, Trifonov VA, Skelton H, Wallis MC, Johnston S, Veyrunes F, Graves JA, Ferguson-Smith MA (2007). The multiple sex chromosomes of platypus and echidna are not completely identical and several share homology with the avian Z. Genome Biology. Nov 16;8(11):R243 [Epub ahead of print]. IF: 7.1
  • Dohm, JC, Tsend-Ayush E, Reinhardt R, Grützner F, Himmelbauer H. (2007). Disruption and pseudoautosomal localization of the Major Histocompatibility Complex in monotremes. Genome Biology 8, R175. IF: 7.1
  • Wallis MC, Delbridge ML, Pask AJ, Alsop AE, Grützner F, O'Brien PC, Rens W, Ferguson-Smith MA, Graves JAM (2007). Mapping platypus SOX genes; autosomal location of SOX9 excludes it from sex determining role. Cytogenet Genome Res. 116(3):232-4. IF: 1.9
  • El-Mogharbel N, Wakefield M, Deakin JE, Tsend-Ayush E, Grützner F, Alsop A, Ezaz T, Graves JAM. (2007). DMRT gene cluster analysis in the platypus: new insights into genomic organization and regulatory regions. Genomics 89(1):10-21. IF: 3.5
  • *Sankovic N, Delbridge ML, Grützner F, Ferguson-Smith MA, O'Brien PC, Marshall Graves JA. (2006). Construction of a highly enriched marsupial Y chromosome-specific BAC sub-library using isolated Y chromosomes. Chromosome Research 14(6):657-664. IF: 3.0
  • Gruetzner F, Ashley T, Rowell DM, Marshall Graves JA. (2006). How did the platypus get its sex chromosome chain? A comparison of meiotic multiples and sex chromosomes in plants and animals. Chromosoma. 115(2):75-88. IF: 3.3
  • *Ezaz T, Valenzuela N, Grützner F, Miura I, Georges A, Burke RL, Marshall Graves JA. (2006). An XX/XY sex microchromosome system in a freshwater turtle, Chelodina longicollis (Testudines: Chelidae) with genetic sex determination. Chromosome Res. 14(2):139-150. IF: 3.0
  • Delbridge ML, Wallis MC, Kirby PJ, Alsop AE, Grützner F, Graves JA. (2006). Assignment of SOX1 to platypus chromosome 20q by fluorescence in situ hybridization. Cytogenet Genome Res. 112(3-4):342. IF: 2.0
  • Yue Y, Tsend-Ayush E, Grützner F, Grossmann B, Haaf T. (2006). Segmental duplication associated with evolutionary instability of human chromosome 3p25.1 Cytogenet Genome Res. 112(3-4):202-207. IF: 2.0
  • Tsend-Ayush E, O'Sullivan LA, Grützner FS, Onnebo SM, Lewis RS, Delbridge ML, Marshall Graves JA, Ward AC. (2005). RBMX gene is essential for brain development in zebrafish. Dev Dyn. 234(3):682-688. IF: 3.3
    Yue Y, Grossmann B, Tsend-Ayush E, Grützner F, Ferguson-Smith MA, Yang F, Haaf T. (2005). Genomic structure and paralogous regions of the inversion breakpoint occurring between human chromosome 3p12.3 and orangutan chromosome 2. Cytogenet Genome Res. 108(1-3):98-105.  IF: 2.0
  • *Rens, W., Grützner, F., O’Brien, P.C.M., Fairclough, H., Graves, J.A.M, Ferguson-Smith, M.A. (2004). Resolution and evolution of the duck-billed platypus karyotype with a X1Y1X2Y2X3Y3X4Y4X5Y5 male sex chromosome constitution. Proceedings of the National Academy of Sciences USA. 101 (46):16257-16261.
  • *Grützner, F., Rens, W., Tsend-Ayush, E., El-Mogharbel, N., O’Brien, P.C.M., Jones, R.C., Ferguson-Smith, M.A., Graves, J.A.M. (2004). In male platypus a meiotic chain of ten chromosomes shares genes with the bird Z and mammal X chromosomes. Nature 432: 913-917 (letter, N&V). (Corresponding author)
  • Grützner, F., Graves, J.A.M. (2004). A Platypus’ eye view of the mammalian genome. Invited review. Current Opinion Genetics &Development. 14(6): 642-649 (cover story). (Corresponding author)
  • Tsend-Ayush E., Grützner, F., Yue, Y., Grossmann, B., Hänsel, U., Sudbrak, R., Haaf, T. (2004). Plasticity of human chromosome 3 during primate evolution. Genomics 83(2): 193-202.
Genome Organisation, Epigenetics and Sex Determination Laboratory

Level 2, Molecular Life Sciences
North Terrace Campus
The University of Adelaide
SA 5005


Frank Grützner
T: +61 8 8313 4812
F: +61 8 8313 4362