Honours Projects in Zebrafish Genetics and Alzheimer's Disease
Honours projects in the Zebrafish Genetics laboratory use molecular genetic, cell biology and bioinformatics techniques to investigate the function of Alzheimer's disease genes.
Projects are planned to give our Honours students a very good chance of obtaining valuable experimental data combined with the excitement of discovering something very novel. All our work is performed with the expectation of possible eventual publication.
We typically accept up to two Honours students to perform molecular projects in our laboratory each year. We can also accept additional Honours students on purely computer-based projects. Many of our Honours graduates have progressed to become Ph.D. students in our laboratory and/or have been employed to use their skills to service the zebrafish research needs of other laboratories. Our graduates have also found employment in other research settings elsewhere in Adelaide and around Australia.
Since our research field is progressing quite rapidly, please contact the lab head, Michael Lardelli, to discuss possible Honours projects.
Some of the techniques in common use in our laboratory include:
- Design of TALEN and CRISPR Cas9 constructs for editing of the zebrafish genome
- Injection into embryos of RNA, DNA, oligonucleotides and protein into embryos to alter gene activity
- In situ transcript hybridisation on whole embryos to observe patterns of gene expression
- Common molecular biology techniques for e.g. gene cloning and sequencing
- Common techniques for protein analysis, e.g. western blotting and immunoprecipitation
- Phylogenetic analysis of gene evolution
- Microscopic analysis of embryo anatomy