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Recent Publications

  • AE Sullivan, A Raimondo, TA Schwab, JB Bruning, P Froguel, IS Farooqi, DJ Peet, ML Whitelaw (2014). Characterisation of human variants in obesity-related SIM1 protein identifies a hotspot for dimerisation with the partner protein ARNT2. Biochem J, in press
  • DC Bersten, JA Wright, PJ McCarthy, ML Whitelaw (2014). Regulation of the Neuronal Transcription Factor NPAS4 by REST and microRNAs. Biochim Biophys Acta  - Gene Regulatory Mechanisms, 1839(1):13-24
  • DC Bersten, JB Bruning, DJ Peet, ML Whitelaw  (2014). Human Variants in the Neuronal basic Helix-Loop-Helix /Per-Arnt-Sim (bHLH/PAS) Transcription Factor Complex NPAS4/ARNT2 Disrupt Function. PLoS One, 17;9(1):e85768
  • DC Bersten, AE Sullivan, DJ Peet and ML Whitelaw (2013). Basic Helix-Loop-Helix / PER-ARNT-    SIM (bHLH/PAS) proteins in cancer.  Nature Rev Cancer, in press, December 2013.
  • S Ramachandrappa, A Raimondo, A Cali, J Keogh, E Henning, S Saeed, A Thompson, S Garg, E    Bochukova, S Brage, V Trowse, E Wheeler, AE Sullivan, M Dattani, P Clayton, V Datta, JB.    Bruning, N Wareham, S O'Rahilly, DJ Peet, I Barroso, ML Whitelaw, SI Farooqi (2013).     Rare variants in Single-minded 1 (SIM1) are associated with severe obesity. J Clin Invest. 123, 3042-50.
  • A Bonnefond, A Raimondo, F Stutzmann, M Ghoussaini, S Ramachandrappa, DC Bersten, E Durand,V Vatin, B Balkau, O Lantieri, V Raverdi, F Pattou, W Van Hul, L Van Gaal, DJ Peet, J Weill, JL. Miller, F Horber, A Goldstone, DJ. Driscoll, JB. Bruning, D Meyre, ML Whitelaw*, P Froguel* (2013). Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-Like-related features.  J Clin Invest. 123, 3037-41.
  • Nan Hao and ML Whitelaw (2013). The emerging roles of AhR in physiology and immunity Biochem Pharmacol 86, 561-70
  • Hao N, Bhakti, VLD, Peet, DJ, Whitelaw ML (2013). Reciprocal regulation of the basic-Helix-Loop-    Helix/Per-Arnt-Sim partner proteins, Arnt and Arnt2, during neuronal differentiation     Nucl. Acid. Res, 41, 5626-38
  • Hao N, Lee KL, Furness SG, Bosdotter C, Poellinger L, Whitelaw ML (2012).  Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling Mol Pharm. 82(6):1082-93
  • Hao N, Whitelaw ML, Shearwin KE, Dodd IB and Chapman-Smith A. (2011) Identification of     residues in the N-terminal PAS domains important for dimerization of Arnt and AhR . Nucl. Acid. Res 39, 3695-2011
  • Whelan F, Hao N, Furness SG, Whitelaw ML and Chapman-Smith A. (2010) Amino acid substitutions in the Aryl Hydrocarbon Receptor (AhR) ligand binding domain reveal YH439 as an atypical AhR activator. Mol Pharm, 77, 1037-46
  • Farrall, AL and Whitelaw ML (2009). The HIF-1α inducible pro-cell death gene BNIP3 is a novel target of SIM2s repression via cross talk on the Hypoxia Response Element. Oncogene, 28(41):3671-80
  • Dave KA, Whelan F, Bindloss C, Furness SG, Chapman-Smith A, Whitelaw ML and Gorman JJ.
    (2009) Sulfonation and phosphorylation of regions of the dioxin receptor susceptible to methionine modifications. Mol Cell Proteomics, 8(4):706-19
  • Woods, S., Farrall, A., Procko, C., and Whitelaw, ML.  (2008) The bHLH/Per-Arnt-Sim transcription
     factor SIM2 regulates muscle transcript myomesin2 via a novel, non-canonical E-box sequence. Nucl. Acids Res. 36, 3716-27
  • Zheng, X., Zheng, X, Linke, S,  Dias, J, Zheng, X, Gradin, K, Wallis, T, Hamilton, B, Gustafsson, M,
    Ruas, j, Wilkins, S, Bilton, R, Brismar, K, Whitelaw, ML, Pereira, T, Gorman, JJ, Ericson, J, Peet, DJ, Lendahl, U, Poellinger, L. (2008) Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Proc. Natl. Acad. Sci. (USA), 105, 3368-3373
  • Furness, SB, Lees, MJ, Whitelaw, ML. (2007) The Dioxin (Aryl hydrocarbon) Receptor as a model for adaptive responses of bHLH/PAS transcription factors. FEBS Letters, 581, 3616-25
  • Dave, KA, Hamilton, BR, Wallis, TP, Furness, SGB, Whitelaw ML, Gorman, JJ. (2007) Identification of N,Ne-dimethyl-lysine in the murine dioxin receptor using MALD-TOF/TOF and ESI-LTQ-Orbitrap-FT-MS. Int. J. Mass Spec., in press
  • Chapman-Smith, A. and Whitelaw, M.L. (2006) Novel DNA binding by a basic helix-loop-helix protein: The role of the dioxin receptor pas domain. J. Biol. Chem. 281, 12535-45
  • Cameron P. Bracken, C.P., Fedele, A.O., Linke, S., Balrak, W., Lisy, K., Whitelaw, M.L. and Peet, D.J. (2006) Cell-specific regulation of HIF-1alpha and HIF-2alpha : Stabilisation and transactivation in a graded oxygen environment. J. Biol. Chem. 281, 22575-85
  • Bracken, C.P., Whitelaw, M.L., Peet, D.J. (2005) Activity of hypoxia-inducible factor 2a is regulated by association with the NF- K B essential modulator. The Journal of Biological Chemistry 280: 14240-51
  • Kewley, R.J., Whitelaw, M.L. (2005) Phosphorylation inhibits DNA-binding of alternatively spliced aryl hydrocarbon receptor nuclear translocator. Biochemical and Biophysical Research Communications 338: 660-7
  • Chapman-Smith, A., Lutwyche, J.K., Whitelaw, M.L. (2004) Contribution of the Per/Arnt/Sim (PAS) domains to DNA binding by the basic helix-loop-helix PAS transcriptional regulators. The Journal of Biological Chemistry 279: 5353-62
  • Kewley, R.J., Whitelaw, M.L., Chapman-Smith, A. (2004) The mammalian basic helix-loop-helix/PAS family of transcriptional regulators. The International Journal of Biochemistry and Cell Biology 36: 189-204
  • Linke, S., Stojkoski, c., Kewley, R.J., Booker, G.W., Whitelaw, M.L., Peet, D.J. (2004) Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor. The Journal of Biological Chemistry 279: 14391-7
  • Peet, D.J., Lando, D., Whelan, D.A., Whitelaw, M.L., Gorman, J.J. (2004) Oxygen-dependent asparagine hydroxylation. Methods in Enzymology 381: 467-87
  • Bracken, C.P, Whitelaw, M.L., Peet, D.J. (2003) The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses. Cellular and Molecular Life Sciences 60: 1376-93
  • Lando, D., Gorman, J.J., Whitelaw, M.L., Peet, D.J. (2003) Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation. European Journal of Biochemistry 270: 781-90
  • Lees, M.J., Peet, D.J., Whitelaw M.L. (2003) Defining the role for XAP2 in stabilization of the dioxin receptor. The Journal of Biological Chemistry 278: 35878-88
  • Anderson, P., McGuire, J., Rubio, C., Gradin, K., Whitelaw, M.L., Petterson, S., Hanburg, A., Poellinger, L. (2002) A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumours. Proceedings of the National Academy of Sciences USA , 99: 9990-5
  • Fedele, A.O., Whitelaw, M.L., Peet, D.P. Regulation of gene expression by the hypoxia inducible factors. Molecular Interventions 2:230-43
  • Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L*., Bruick, R. K*. (2002) FIH is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of Hypoxia Inducible Factor. Genes and Development, 16, 1466-71. (*joint senior author)
  • Lando, D., Peet, D.J., Pongratz, I., Whitelaw, M.L. (2002) Mammalian Two-Hybrid Assay Showing Redox Control of HIF-Like Factor. Methods in Enzymology , Vol. 353
  • Lando, D., Peet, D.J., Whelan, D.A., Gorman, J.J., Whitelaw, M.L. (2002) Asparagine Hydroxylation of the HIF Transactivation Domain: A hypoxic Switch. Science 295:858-61
  • Lees, M.J., Whitelaw, M.L. (2002) Mediation of dioxin receptor transcription by Ara9(XAP/AIP) Toxicology 181-182:143-6
  • Swanson, H.I., Whitelaw, M.L., Petrulis, J.R. and Perdew, G.H. (2002) Use of [1251]4'-Iodoflavone as a tool to characterize ligand dependant differences I Ah receptor behaviour. Journal of biochemical and molecular toxicology 16: 298-310
  • Woods, S., Whitelaw, M.L. (2002) Differential activities of murine SIM1and SIM2 on a hypoxic response element: Crosstalk between bHLH/PAS transcription factors. The Journal of Biological Chemistry 277:10236-43
  • McGuire, J., Okamoto, K., Whitelaw, M.L., Tanaka, H., Poellinger, L. (2001) Definition of a Dioxin Receptor Mutant that is a Constitutive Activator of Transcription. Journal of Biological Chemistry, 276, 41841-41849
  • Lando, D., Pongratz, I., Poellinger, L., Whitelaw, M.L. (2000) A Redox Mechanism Controls Differential DNA Binding Activities of the Hypoxia Inducible Factors HIF-1a and HIF-Like-Factor, Journal of Biological Chemistry, 275, 4618-4628
Whitelaw Laboratory
Address

North Terrace Campus
Level 3, Molecular Life Sciences
The University of Adelaide
SA 5005
AUSTRALIA

Contact

Murray Whitelaw
T: +61 8 8313 4724
F: +61 8 8313 4362
email