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Selected Landmark Publications from the Paton Laboratory

  • Paton, A.W., Morona, R., and Paton, J.C. (2000). A new biological agent for treatment of Shiga toxigenic Escherichia coli infections and dysentery in humans. Nature Medicine, 6:265-270.
  • Brown, J.S., Hussell, T., Gilliland, S.M., Holden, D.W., Paton, J.C., Ehrenstein, M., Walport, M.J., and Botto, M. (2002). The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice. Proc. Natl. Acad. Sci. USA. 99:16969-74.
  • Malley, R., Henneke, P., Morse, S.C., Cieslewicz, M.J., Lipsitch, M., Thompson, C.M., Kurt-Jones, E., Paton, J.C., Wessels, M.R., and Golenbock, D. (2003). Recognition of pneumolysin by Toll-like receptor (TLR) 4 confers resistance to pneumococcal infection. Proc. Natl. Acad. Sci. USA. 100: 1966-1971.
  • Paton, A.W., Srimanote, P., Talbot, U.M., Wang, H., and Paton, J.C. (2004). A new family of potent AB5 cytotoxins produced by Shiga toxigenic Escherichia coli. J. Exp. Med. 200:35-46.
  • Paton, A.W., Jennings, M.P., Morona, R., Focareta, A., Roddam, L.F., and Paton, J.C. (2005). Recombinant probiotics for treatment and prevention of travellers’ diarrhea. Gastroenterology 128: 1219-1228.
  • Standish, A.J., Stroeher, U.H., and Paton, J.C. (2005). The two-component signal transduction system RR06/HK06 regulates expression of cbpA in Streptococcus pneumoniae. Proc. Natl. Acad. Sci. USA. 102:7701-7706.
  • Paton, A.W., Morona, R., and Paton, J.C. (2006). Designer probiotics for prevention of enteric infections. Nature Reviews Microbiology. 4: 193-200.
  • Focareta, A., Paton, J.C., Morona, R., Cook, J., and Paton, A.W. (2006). A recombinant probiotic for treatment and prevention of cholera. Gastroenterology. 130: 1688-1695.
  • Paton, A.W., Beddoe, T., Thorpe, C.M., Whisstock, J.C., Wilce, M.C.J., Rossjohn, J., Talbot, U.M. and Paton J.C. (2006). AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP. Nature. 443: 548-552.
  • Morona, J.K., Morona, R., and Paton, J.C. (2006). Attachment of capsular polysaccharide to the cell wall of Streptococcus pneumoniae type 2 is required for invasive disease. Proc. Natl. Acad. Sci. USA. 103: 8505-8510.
  • Maus, U.A., Backi, M., Winter, C., Srivastava, M., Schwarz, M.K., Rückle, T., Paton, J.C., Briles, D.E., Mack, M., Welte, T., Maus, R., Bohle, R.M., Seeger, W., Rommel, C., Hirsch, E., Lohmeyer, J., and Preissner, K.T. (2007). Importance of phosphoinositide 3-kinase g in host defense against pneumococcal infection. Am J. Resp. Crit. Care. Med. 175:958-966.
  • Kadioglu, A., Weiser, J.N., Paton, J.C., and Andrew, P.W. (2008). The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease. Nature Rev. Microbiol. 6: 288-301.
  • Chong, D.C., Paton, J.C., Thorpe, C.M., and Paton, A.W. (2008). Clathrin-dependent trafficking of subtilase cytotoxin, a novel AB5 toxin that targets the endoplasmic reticulum chaperone BiP. Cell. Microbiol. 10: 795-806.
  • Byres, E., Paton, A.W., Paton, J.C., Löfling, J.C., Smith, D.F., Wilce, M.C.J., Talbot, U.M., Chong, D.C., Yu, H., Huang, S., Chen, X., Varki, N.M., Varki, A., Rossjohn, J., and Beddoe, T. (2008). Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin. Nature. 456: 648-652.
  • Ogunniyi, A.D., Grabowicz, M., Mahdi, L.K., Cook, J., Gordon, D.L., Sadlon, T.A., and Paton, J.C. (2009). Pneumococcal histidine triad proteins are regulated by the Zn2+-dependent repressor AdcR and inhibit complement deposition through the recruitment of complement factor H. FASEB J. 23:731-738.
  • Hu, C.A., Dougan, S.K., Winter, S.V., Paton, A.W., Paton, J.C., and Ploegh, H.L. (2009). Subtilase cytotoxin cleaves newly synthesised BiP and blocks antibody secretion in B lymphocytes. J. Exp. Med. 206: 2429-2440.
  • Paton, J.C., and Ogunniyi, A.D. (2011). Evicting the pneumococcus from its nasopharyngeal lodgings. Cell Host & Microbe. 9: 89-91.
  • Goodwin, E.C., Lipovsky, A., Inoue, T., Magaldi, T.G., Edwards, A.P.B., Van Goor, K.E.Y., Paton, A.W., Paton, J.C., Atwood, W.J., Tsai, B., and DiMaio, D. (2011). BiP and multiple DNAJ molecular chaperones in the endoplasmic reticulum are required for efficient SV40 infection. mBio. 2: e00101-11.
  • McDevitt, C.A., Ogunniyi, A.D., Valkov, E., Lawrence, M.C., Kobe, B., McEwan, A.G., and Paton, J.C. (2011). A molecular mechanism for bacterial susceptibility to zinc. PLoS Pathogens. 7:e1002357.
  • Weber, M., Lambeck, S., Ding, S., Henken, S., Kohl, M., Deigner, H.P., Enot, D.P., Igwe, E.I., Frappart, L., Kiehntopf, M., Claus, R.A., Kamradt, T., Weih, D., Vodovotz, Y., Briles, D.E., Ogunniyi, A.D., Paton, J.C., Maus, U.A., and Bauer, M. (2012). Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia. FASEB J. 26:2424-2436.
  • Mahdi, L.K., Wang, H., Van der Hoek, M.B., Paton, J.C., and Ogunniyi, A.D. (2012). Identification of a novel pneumococcal vaccine antigen preferentially expressed during meningitis in mice. J. Clin. Invest. 122:2208-2220.
  • Schäuble, N., Lang, S., Jung, M., Cappel, S., Schorr, S., Ulukan, O., Linxweiler, J., Dudek, J., Blum, R., Helms, V., Paton, A.W., Paton, J.C., Cavalié, A., and Zimmermann, R. (2012) BiP-mediated closing of the Sec61 channel via loop 7 interaction limits Ca2+ leakage from the ER. EMBO J. 31: 3282-3296.
  • Heijmans, J., van Lidth de Jeude, J.F., Koo, B.K., Rosekrans, S.L., Wielenga, M.C.B., van de Wetering, M., Ferrante, M., Lee, A.S., Onderwater, J.J.M., Paton, J.C., Paton, A.W., Mommaas, A.M., Kodach, L.L., Hardwick, J.C., Hommes, D.W., Clevers, H., Muncan, V., and van den Brink, G.R. (2013). ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. Cell Reports 3: 1-12.
  • Shak, J.R., Ludewick, H.P., Sakai, F., Harvey, R.M., Paton, J.C., Klugman, K.P., and Vidal, J.E. (2013). A novel role for the Streptococcus pneumoniae toxin pneumolysin in the assembly of biofilms. mBio. 4: e00655-13.
  • Couñago, R.M., Ween, M.P., Begg, S.L., Bajaj, M., Zuegg, J., O'Mara, M.L., Cooper, M.A., McEwan, A.G., Paton, J.C., Kobe, B., and McDevitt, C.A. (2014). Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chem. Biol. 10: 35-41.
  • Lu, M., Lawrence, D.A., Marsters, S., Acosta-Alvear, D., Kimmig, P., Mendez, A., Paton, A.W., Paton, J.C., Walter, P., and Ashkenazi, A. (2014). Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis. Science 342:98-101.
  • Fucho1, R., Martínez, L., Baulies, A., Tarrats, N., Fernandez, A., Ribas, V., Astudillo, A.M., Balsinde, J., Garcia-Rovés, P., Elena, M., Bergheim, I., Lotersztajn, S., Trautwein, C., Appelqvist, H., Paton, A.W., Paton, J.C., Kaplowitz, N., Fernandez-Checa, J.C., and García-Ruiz, C. (2014). ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis. J. Hepatol. 61:1126-1134.
  • Manso, A.S., Chai, M.H., Atack, J.M., Furi, L., Croix, M.D.S., Haigh, R., Trappetti, C., Ogunniyi, A.D., Shewell, L.K., Boitano, M., Clark, T.A., Korlach, J., Blades, M., Mirkes, E., Gorban, A., Paton, J.C., Jennings, M.P., and Oggioni, M.R. (2014). A random six-phase switch regulates pneumococcal virulence via global epigenetic changes. Nature Commun. 5:5055 (doi: 10.1038/ncomms6055).
  • Ng, P.S.K., Böhm, R., Hartley-Tassell, L.E., Steen, J.A., Wang, H., Lukowski, S.W., Hawthorne, P.L., Trezise, A.E.O., Coloe, P.J., Grimmond, S.M., Haselhorst, T., von Itzstein, M., Paton, A.W., Paton, J.C., and Jennings, M.P. (2014). Ferrets lack CMAH, exclusively synthesize Neu5Ac and expressed naturally humanized influenza A virus receptors. Nature Commun. In press.
Bacterial Pathogenesis Laboratory
Address

North Terrace Campus
Level 4, Molecular Life Sciences
The University of Adelaide
SA 5005
AUSTRALIA

Contact

James Paton
T: +61 8 8313 5929
F: +61 8 8313 3262
Email