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Receptor Mimic Technology

This research is conducted in collaboration with Professor James Paton and Dr Adrienne Paton, and is based on Escherchia coli strains with genetically modified lipopolysaccharides that mimic human glycolipids, and can act as receptor mimics for bacterial toxins thereby acting as novel therapeutic agents.

Relevant publications

Watts, R.E., Tan C.K., Ulett, G.C., Carey, A.J., A.J., Totsika, M., Idris, A., Paton, A.W., Morona, R., Paton, J.C., and Schembri, M.A. (2012) Escherichia coli 83972 expressing a P fimbriae oligosaccharide receptor mimic impairs adhesion of uropathogenic E. coli. J. Infect. Dis. 206:1242-1249.

Paton, A.W., Morona, R., and Paton JC. (2012) Bioengineered microbes in disease therapy. Trends Mol. Med. 18:417-425.

Paton, A.W, Morona, R., and Paton J.C. (2010) Receptor-mimic probiotics: potential therapeutics for bacterial toxin-mediated enteric diseases. Expert Rev Gastroenterol Hepatol. 4:253-255

Paton, A.W., Morona, R., and Paton, J.C. (2010). Bioengineered bugs expressing oligosaccharide receptor mimics: toxin-binding probiotics for treatment and prevention of enteric infections. Bioengineered Bugs. 1:172-177.

Paton, A.W, Morona, R., and Paton, J.C. (2006) Designer probiotics for prevention of enteric infections". Nat. Rev. Microbiol. 4:193-200.

Focareta, A., Paton, J.C., Morona, R., Cook, J., and Paton, A.W. (2006) A recombinant probiotic for treatment and prevention of cholera”. Gastroenterology 130: 1688-1695.

Paton, A.W., Jennings, M.P., Morona, R., Wang, H., Focareta, A., Roddam, L.F., and Paton, J.C. (2005) Recombinant probiotics for treatment and prevention of enterotoxigenic Escherichia coli diarrhea. Gastroenterology 128: 1219-1228.

Pinyon, R., Paton, J.C., Paton, A.W., James A. Botten, J.A., and Morona, R. (2004) Refinement of a therapeutic Shiga toxin-binding probiotic for human trials. J. Infect. Dis. 189: 1547-1555.

Paton, A.W., Morona, R., and Paton, J.C. (2001) Neutralisation of Shiga toxins Stx1, Stx2c and Stx2e by recombinant bacteria expressing mimics of globotriose and globotetraose. Infect. Immun. 69: 1967-1970.

Paton, J.C., Rodgers, T.J., Morona, R., and Paton, A.W. (2001) Oral administration of formaldehyde-killed recombinant bacteria expressing a mimic of the shiga toxin receptor protects mice from fatal challenge with Shiga-toxigenic Escherichia coli. Infect. Immun. 69: 1389-1393.

Paton, A., Morona, R., and Paton, J.C. (2000) A novel biological agent for treatment of Shiga toxigenic Escherichia coli infections and dysentery in humans. Nature Medicine 6: 265-270.


Invasive Bacterial Pathogens Laboratory
Address

North Terrace Campus
Level 4, Molecular Life Sciences
The University of Adelaide
SA 5005
AUSTRALIA

Contact

Renato Morona
T: +61 8 8313 4151
F: +61 8 8313 7532
Email