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Anti-Microbial Drug Discovery

In recent studies drugs acting on novel bacterial target have been discovered in several collaborative projects.

Relevant Publications:

Standish, A.J., Salim, A.A., Capon, R.J., and Morona R. (2013) Dual inhibition of DNA polymerase PolC and protein tyrosine phosphatase CpsB uncovers a novel antibiotic target. Biochem Biophys Res Commun. 430:167-172.

Ericsson, D.J., Standish, A, Kobe, B., and Morona, R. (2012) Wzy-dependent bacterial capsules as potential drug targets. Curr Drug Targets. 13:1421-1431.

Standish, A.J, Salim, A.A., Capon, R.J, and Morona, R. Chemical inhibition of bacterial protein tyrosine phosphatase suppresses capsule production. (2012) PLoS ONE 7(5): e36312. doi:10.1371/journal.pone.0036312.

Zvarec, O., Polyak, S.W., Tieu, W., Kwan, K., Dai, H., Sejer Pedersen, D., Morona, R., Zhang, L., Booker, G.W. and Abell, A.D. (2012) Novel 5-benzylidenerhodanine and 5-benzylidene-2-4-thiazolidinedione scaffolds containing optically active amino acids: a antibacterial activity study. Bioorg. Med. Chem. Letts. 22:2720-2722

Soares da Costa, T.P., Tieu, W., Yap, M.Y., Pendini, N.R., Polyak, S.W., Sejer Pedersen, D., Morona, R., Turnidge, J.D., Wallace, J.C., Wilce, M.C., Booker, G.W., Abell, A.D. (2012) Selective inhibition of biotin protein ligase from Staphylococcus aureus. J. Biol. Chem. 87:17823-17832.
Invasive Bacterial Pathogens Laboratory
Address

North Terrace Campus
Level 4, Molecular Life Sciences
The University of Adelaide
SA 5005
AUSTRALIA

Contact

Renato Morona
T: +61 8 8313 4151
F: +61 8 8313 7532
Email